Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review.
circulating tumor DNA (ctDNA)
circulating tumor cell (CTC)
exosome
liquid biopsy
miRNA
multi-omics
personalized medicine
tumor biomarker
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
01
2023
accepted:
20
03
2023
medline:
20
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
In the last years, liquid biopsy gained increasing clinical relevance for detecting and monitoring several cancer types, being minimally invasive, highly informative and replicable over time. This revolutionary approach can be complementary and may, in the future, replace tissue biopsy, which is still considered the gold standard for cancer diagnosis. "Classical" tissue biopsy is invasive, often cannot provide sufficient bioptic material for advanced screening, and can provide isolated information about disease evolution and heterogeneity. Recent literature highlighted how liquid biopsy is informative of proteomic, genomic, epigenetic, and metabolic alterations. These biomarkers can be detected and investigated using single-omic and, recently, in combination through multi-omic approaches. This review will provide an overview of the most suitable techniques to thoroughly characterize tumor biomarkers and their potential clinical applications, highlighting the importance of an integrated multi-omic, multi-analyte approach. Personalized medical investigations will soon allow patients to receive predictable prognostic evaluations, early disease diagnosis, and subsequent
Identifiants
pubmed: 37077538
doi: 10.3389/fgene.2023.1152470
pii: 1152470
pmc: PMC10109350
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1152470Informations de copyright
Copyright © 2023 Di Sario, Rossella, Famulari, Maurizio, Lazarevic, Giannese and Felici.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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