Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1.
atherosclerosis
foam cells
heat shock factor 1
heat shock proteins
lipid metabolism
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
01
2023
accepted:
15
03
2023
medline:
20
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
Atherosclerosis is a major risk factor for cardiovascular diseases. Hypercholesterolemia has been both clinically and experimentally linked to cardiovascular disease and is involved in the initiation of atherosclerosis. Heat shock factor 1 (HSF1) is involved in the control of atherosclerosis. HSF1 is a critical transcriptional factor of the proteotoxic stress response that regulates the production of heat shock proteins (HSPs) and other important activities such as lipid metabolism. Recently, HSF1 is reported to directly interact with and inhibit AMP-activated protein kinase (AMPK) to promote lipogenesis and cholesterol synthesis. This review highlights roles of HSF1 and HSPs in critical metabolic pathways of atherosclerosis, including lipogenesis and proteome homeostasis.
Identifiants
pubmed: 37077734
doi: 10.3389/fcvm.2023.1155444
pmc: PMC10106699
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1155444Subventions
Organisme : NCI NIH HHS
ID : K22 CA248616
Pays : United States
Informations de copyright
© 2023 Ghai, Young and Su.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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