Synthesis and screening of cyclic diketone indanedione derivatives as future scaffolds for neutrophil elastase inhibition.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
11 Apr 2023
11 Apr 2023
Historique:
received:
12
01
2023
accepted:
23
03
2023
medline:
20
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
Human neutrophil elastase (HNE) and proteinase 3 (Pr3) released from neutrophils at inflammatory sites are the major causes of pathogens in chronic obstructive pulmonary disease (COPD) and various lung tissue derangements, among which cystic fibrosis and blockade of airway passages are chronic. These proteolytic mediatory agents combined with induced oxidative reactions sustain pathogenicity. Cyclic diketone indane-1,3-dione derivatives were designed, and toxicity evaluation predictions were performed
Identifiants
pubmed: 37077993
doi: 10.1039/d3ra00106g
pii: d3ra00106g
pmc: PMC10107027
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11838-11852Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
Références
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2228-32
pubmed: 3550808
Bioorg Med Chem. 2006 Dec 15;14(24):8467-87
pubmed: 16971130
Chem Rev. 2002 Dec;102(12):4501-24
pubmed: 12475199
J Med Chem. 2007 Jul 12;50(14):3205-13
pubmed: 17559204
J Biomol Struct Dyn. 2022 Jul;40(11):4866-4878
pubmed: 33345726
Chem Rev. 2002 Dec;102(12):4639-750
pubmed: 12475205
Int J Biochem Cell Biol. 2008;40(6-7):1317-33
pubmed: 18180196
Expert Opin Ther Pat. 2018 Feb;28(2):93-110
pubmed: 29171765
Mucosal Immunol. 2021 Jul;14(4):815-827
pubmed: 33758367
RSC Adv. 2021 Apr 7;11(22):13051-13060
pubmed: 35423848
Curr Drug Res Rev. 2021;13(1):73-83
pubmed: 32955008
Mol Divers. 2016 Feb;20(1):111-52
pubmed: 25957619
J Chem Inf Model. 2014 Apr 28;54(4):1070-82
pubmed: 24665947
Chem Biol Drug Des. 2010 Apr;75(4):348-59
pubmed: 20331649
Bioorg Med Chem Lett. 2002 Sep 2;12(17):2359-62
pubmed: 12161133
J Biomol Struct Dyn. 2022 May;40(8):3609-3625
pubmed: 33226303
Biomed J. 2021 Aug;44(4):439-446
pubmed: 33087299
J Pharm Sci. 2016 Feb;105(2):497-508
pubmed: 26173749
J Med Chem. 1999 Jul 29;42(15):2969-76
pubmed: 10425106
Biochemistry. 1989 Mar 7;28(5):1951-63
pubmed: 2655701
Mini Rev Med Chem. 2018;18(15):1321-1330
pubmed: 29600759
Acta Pharmacol Sin. 2014 May;35(5):685-96
pubmed: 24786236
Mini Rev Med Chem. 2021;21(17):2612-2625
pubmed: 33397237