Impact of aging on immune function in the pathogenesis of pulmonary diseases: potential for therapeutic targets.
Aging
COPD
Cellular senescence
Cytokines
IPF
Immunity
Lymphocytes
Journal
Expert review of respiratory medicine
ISSN: 1747-6356
Titre abrégé: Expert Rev Respir Med
Pays: England
ID NLM: 101278196
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
pmc-release:
01
05
2024
medline:
14
6
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
ppublish
Résumé
Several immunological alterations that occur during pulmonary diseases often mimic alterations observed in the aged lung. From the molecular perspective, pulmonary diseases and aging partake in familiar mechanisms associated with significant dysregulation of the immune systems. Here, we summarized the findings of how aging alters immunity to respiratory conditions to identify age-impacted pathways and mechanisms that contribute to the development of pulmonary diseases. The current review examines the impact of age-related molecular alterations in the aged immune system during various lung diseases, such as COPD, IPF, Asthma, and alongside many others that could possibly improve on current therapeutic interventions. Moreover, our increased understanding of this phenomenon may play a primary role in shaping immunomodulatory strategies to boost outcomes in the elderly. Here, the authors present new insights into the context of lung-related diseases and describe the alterations in the functioning of immune cells during various pulmonary conditions altered with age. The expert opinion provided the concepts on how aging alters immunity during pulmonary conditions, and suggests the associated mechanisms during the development of lung diseases. As a result, it becomes important to comprehend the complex mechanism of aging in the immune lung system.
Identifiants
pubmed: 37078192
doi: 10.1080/17476348.2023.2205127
pmc: PMC10330361
mid: NIHMS1897255
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-364Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL158316
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135613
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147715
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029177
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL167655
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133404
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG075931
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137738
Pays : United States
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