Mediator structure and function in transcription initiation.
RNA polymerase II
coactivator
gene regulation
mediator
transcription
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
26 07 2023
26 07 2023
Historique:
received:
10
03
2023
accepted:
06
04
2023
medline:
8
9
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.
Identifiants
pubmed: 37078249
pii: hsz-2023-0158
doi: 10.1515/hsz-2023-0158
doi:
Substances chimiques
RNA Polymerase II
EC 2.7.7.-
Mediator Complex
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-837Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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