Solitary fibrous tumor of the thyroid: report of three cases with a focus on cytological features and histological clues for malignancy.
Malignant solitary fibrous tumor
Primary location
STAT6 expression, FNA cytology
Solitary fibrous tumor
Thyroid gland
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
11
12
2022
accepted:
12
04
2023
revised:
09
04
2023
medline:
10
8
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
ppublish
Résumé
Solitary fibrous tumor is a mesenchymal tumor of intermediate malignant potential characterized by a recurrent NAB2::STAT6 fusion and STAT6 nuclear expression. Primary thyroid solitary fibrous tumor is relatively uncommon, with 45 cases described in the English literature to date. Although its histologic features are characteristic, its diagnosis in the thyroid can be problematic, especially in small biopsies or cytology specimens. We herein present three new cases of thyroid solitary fibrous tumor, one of which is malignant, with new insights on the morphological spectrum and malignant potential of this tumor. We additionally provide a review of the literature with a focus on the clues and challenges of a preoperative cytological diagnosis of this tumor, which can nowadays be supported by STAT6 nuclear expression, when appropriately suspected.
Identifiants
pubmed: 37079094
doi: 10.1007/s00428-023-03542-5
pii: 10.1007/s00428-023-03542-5
doi:
Substances chimiques
STAT6 Transcription Factor
0
Biomarkers, Tumor
0
Types de publication
Review
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-250Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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