Oncogenic


Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
21 04 2023
Historique:
medline: 24 4 2023
pubmed: 20 4 2023
entrez: 20 04 2023
Statut: ppublish

Résumé

RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 (

Identifiants

pubmed: 37079685
doi: 10.1126/science.abn7625
pmc: PMC10184553
mid: NIHMS1894514
doi:

Substances chimiques

Carcinogens 0
CDC2 Protein Kinase EC 2.7.11.22
CDK13 protein, human EC 2.7.11.22
RNA, Nuclear 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabn7625

Subventions

Organisme : NCI NIH HHS
ID : K08 CA248727
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163222
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA103846
Pays : United States

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Auteurs

Megan L Insco (ML)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Brian J Abraham (BJ)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Sara J Dubbury (SJ)

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Ines H Kaltheuner (IH)

Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.

Sofia Dust (S)

Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.

Constance Wu (C)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Kevin Y Chen (KY)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

David Liu (D)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Stanislav Bellaousov (S)

University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Anna M Cox (AM)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Benjamin J E Martin (BJE)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Tongwu Zhang (T)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.

Calvin G Ludwig (CG)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Tania Fabo (T)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Rodsy Modhurima (R)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Dakarai E Esgdaille (DE)

University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Telmo Henriques (T)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Kevin M Brown (KM)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.

Matthias Geyer (M)

Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.

Karen Adelman (K)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Phillip A Sharp (PA)

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Richard A Young (RA)

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Paul L Boutz (PL)

University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Center for Biomedical Informatics, University of Rochester, Rochester, NY 14642, USA.

Leonard I Zon (LI)

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

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Classifications MeSH