Use of Intracameral Tissue Plasminogen Activator During Uveitic Cataract Surgery.
Cataract surgery
intraocular inflammation
postoperative inflammation
tissue plasminogen activator
uveitis
Journal
Ocular immunology and inflammation
ISSN: 1744-5078
Titre abrégé: Ocul Immunol Inflamm
Pays: England
ID NLM: 9312169
Informations de publication
Date de publication:
20 Apr 2023
20 Apr 2023
Historique:
pmc-release:
20
10
2024
medline:
20
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
aheadofprint
Résumé
To report the outcomes of intracameral tissue plasminogen activator (tPA) use during uveitic cataract surgery. Retrospective case series from a single United States tertiary center of 36 eyes from 31 consecutive patients with established uveitis who received intraoperative intracameral tPA during cataract surgery between 2016 and 2020. Mean visual acuity (VA) improved from logMAR 1.0 ± 0.7 preoperatively to logMAR 0.7 ± 0.8 by POM12. VA improved from baseline postoperatively (POM1 Adjunctive intracameral tPA during uveitic cataract surgery improves VA and intraocular inflammation, but risks postoperative hemorrhage. Intraoperative tPA as adjunctive anti-inflammatory therapy warrants randomized prospective studies.
Identifiants
pubmed: 37079881
doi: 10.1080/09273948.2023.2194410
pmc: PMC10587359
mid: NIHMS1925117
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NCATS NIH HHS
ID : UM1 TR004409
Pays : United States
Références
J Cataract Refract Surg. 1991 Sep;17(5):543-6
pubmed: 1941585
Am J Ophthalmol. 1988 Dec 15;106(6):719-22
pubmed: 3143267
Exp Eye Res. 1987 Jan;44(1):55-63
pubmed: 3104075
BMC Ophthalmol. 2020 Mar 17;20(1):109
pubmed: 32183739
Retin Cases Brief Rep. 2012 Summer;6(3):290-3
pubmed: 25389735
Ophthalmology. 1990 Feb;97(2):184-9
pubmed: 2109297
Int J Ophthalmol. 2021 May 18;14(5):676-683
pubmed: 34012881
Ophthalmologe. 1999 Sep;96(9):587-93
pubmed: 10501987
Br J Ophthalmol. 1998 Jul;82(7):810-5
pubmed: 9924378
Br J Ophthalmol. 2005 Nov;89(11):1458-61
pubmed: 16234453
Br J Ophthalmol. 2000 Sep;84(9):983-6
pubmed: 10966949
Br J Ophthalmol. 2014 Feb;98(2):252-5
pubmed: 24276695
J Cataract Refract Surg. 1997 Jul-Aug;23(6):873-7
pubmed: 9292671
Am J Ophthalmol. 2014 Oct;158(4):676-692.e7
pubmed: 24983790
Int Ophthalmol. 1994-1995;18(5):277-80
pubmed: 7607808