Extractive-liquid sampling electron ionization-mass spectrometry (E-LEI-MS): a new powerful combination for direct analysis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 Apr 2023
20 Apr 2023
Historique:
received:
01
02
2023
accepted:
17
04
2023
medline:
21
4
2023
pubmed:
21
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
One of modern analytical chemistry main challenges is providing as fast as possible results in different application fields. In this view, real-time analysis techniques are experiencing ever-increasing success as they can provide data quickly, almost without sample preparation steps. Most of real-time approaches are based on direct mass spectrometry (DMS), a method of analyzing samples without the need for separation or pre-treatment steps. Instead, the sample is directly introduced into the mass spectrometer for analysis. In this context, ambient ionization mass spectrometry (AIMS) techniques are widely represented and successfully used. Extractive-liquid sampling electron ionization-mass spectrometry (E-LEI-MS) represents a different analytical strategy that allows coupling ambient sampling with electron ionization (EI), avoiding any sample preparation step and providing identification based on the comparison with the National Institute of Standards and Technology (NIST) library spectra. E-LEI-MS consists of a dispositive for solvent release and sampling at ambient conditions coupled with an EI source of a single quadrupole mass spectrometer. A micromanipulator allows fine (x,y,z) positioning of a sampling tip. MS can operate in scan or SIM modes depending on the application goals and requirements. Several preliminary successful results were already obtained due to the highly informative EI mass spectra generation. The system was applied to the analysis of active ingredients in pharmaceutical tablets, pesticides on fruit peel, a drug of abuse (cocaine) determination in banknotes, and analysis of unknown components on painting surfaces. Both forensic and artwork applications allowed determining the spatial distribution of the analytes. Here we present a proof-of-concept of E-LEI-MS for targeted/non-targeted analysis and semi-quantitative detection.
Identifiants
pubmed: 37081134
doi: 10.1038/s41598-023-33647-5
pii: 10.1038/s41598-023-33647-5
pmc: PMC10119378
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6429Informations de copyright
© 2023. The Author(s).
Références
Talanta. 2022 Feb 1;238(Pt 2):123046
pubmed: 34801903
Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1329-34
pubmed: 23681810
Drug Test Anal. 2015 Oct;7(10):884-93
pubmed: 25800348
Anal Chem. 2014 Jan 7;86(1):233-49
pubmed: 24308499
Rapid Commun Mass Spectrom. 2005;19(16):2305-12
pubmed: 16021617
Mass Spectrom Rev. 2001 Mar-Apr;20(2):88-104
pubmed: 11455563
Talanta. 2018 May 1;181:204-209
pubmed: 29426502
Science. 2006 Mar 17;311(5767):1566-70
pubmed: 16543450
Forensic Chem. 2017 Jun;4:108-115
pubmed: 29251300
Anal Chem. 2005 Apr 15;77(8):2297-302
pubmed: 15828760
Anal Chem. 2005 Nov 1;77(21):6915-27
pubmed: 16255590
Rapid Commun Mass Spectrom. 2012 May 15;26(9):1109-14
pubmed: 22467461
Anal Chim Acta. 2021 Jul 4;1167:338350
pubmed: 34049632
Anal Chem. 2019 Apr 2;91(7):4266-4290
pubmed: 30790515
Mass Spectrom Rev. 2020 Sep;39(5-6):703-744
pubmed: 32048319
Anal Chem. 2020 Jul 21;92(14):10076-10082
pubmed: 32538619
Science. 2004 Oct 15;306(5695):471-3
pubmed: 15486296