The degree and position of phosphorylation determine the impact of toxic and trace metals on phosphoinositide containing model membranes.
Lipid domains
Lipid-metal interactions
Liposomes
Membrane fluidity
Model membranes
Phosphatidylinositol
Journal
BBA advances
ISSN: 2667-1603
Titre abrégé: BBA Adv
Pays: Netherlands
ID NLM: 9918227371406676
Informations de publication
Date de publication:
2021
2021
Historique:
medline:
3
8
2021
pubmed:
3
8
2021
entrez:
21
04
2023
Statut:
epublish
Résumé
This work assessed effects of metal binding on membrane fluidity, liposome size, and lateral organization in biomimetic membranes composed of 1 mol% of selected phosphorylated phosphoinositides in each system. Representative examples of phosphoinositide phosphate, bisphosphate and triphosphate were investigated. These include phosphatidylinositol-(4,5)-bisphosphate, an important signaling lipid constituting a minor component in plasma membranes whereas phosphatidylinositol-(4,5)-bisphosphate clusters support the propagation of secondary messengers in numerous signaling pathways. The high negative charge of phosphoinositides facilitates electrostatic interactions with metals. Lipids are increasingly identified as toxicological targets for divalent metals, which potentially alter lipid packing and domain formation. Exposure to heavy metals, such as lead and cadmium or elevated levels of essential metals, like cobalt, nickel, and manganese, implicated with various toxic effects were investigated. Phosphatidylinositol-(4)-phosphate and phosphatidylinositol-(3,4,5)-triphosphate containing membranes are rigidified by lead, cobalt, and manganese whilst cadmium and nickel enhanced fluidity of membranes containing phosphatidylinositol-(4,5)-bisphosphate. Only cobalt induced liposome aggregation. All metals enhanced lipid clustering in phosphatidylinositol-(3,4,5)-triphosphate systems, cobalt in phosphatidylinositol-(4,5)-bisphosphate systems, while all metals showed limited changes in lateral film organization in phosphatidylinositol-(4)-phosphate matrices. These observed changes are relevant from the biophysical perspective as interference with the spatiotemporal formation of intricate domains composed of important signaling lipids may contribute to metal toxicity.
Identifiants
pubmed: 37082006
doi: 10.1016/j.bbadva.2021.100021
pii: S2667-1603(21)00020-X
pmc: PMC10074965
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100021Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with the contents of this article. Supplementary Information accompanies this paper.
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