The histologic reaction and permanence of hyaluronic acid gel, calcium hydroxylapatite microspheres, and extracellular matrix bio gel.
calcium hydroxylapatite
extracellular matrix
hyaluronic acid
soft tissue fillers
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
24
03
2023
received:
06
02
2023
accepted:
28
03
2023
medline:
20
9
2023
pubmed:
21
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
The filling materials on the beauty market can be classified into three types: natural biological materials, synthetic polymer materials, and composites containing bioactive substances. However, comparative experimental data is lacking to compare their biological responses and permanence. The main object of this study was to evaluate the biological response of these three types of fillers to provide a theoretical basis for clinical application. Six-week-old female mice were injected subcutaneously with hyaluronic acid (HA) gel, calcium hydroxylapatite (CaHA) microspheres, and extracellular matrix (ECM) bio gel to observe the body reaction and permanence. At 1, 4, 8, and 16 weeks, the test sites were excised and analyzed by histopathology and proteomics. Extracellular matrix had a minimal foreign body response. HA had a good volume effect at the early stage but the volume retention rate was lower than CaHA in the long term. CaHA could stimulate neo-collagen formation. This study has proven the effectiveness and safety of these fillers and could provide clinical guidance for the plastic surgeon.
Sections du résumé
BACKGROUND
BACKGROUND
The filling materials on the beauty market can be classified into three types: natural biological materials, synthetic polymer materials, and composites containing bioactive substances. However, comparative experimental data is lacking to compare their biological responses and permanence.
AIMS
OBJECTIVE
The main object of this study was to evaluate the biological response of these three types of fillers to provide a theoretical basis for clinical application.
METHODS
METHODS
Six-week-old female mice were injected subcutaneously with hyaluronic acid (HA) gel, calcium hydroxylapatite (CaHA) microspheres, and extracellular matrix (ECM) bio gel to observe the body reaction and permanence. At 1, 4, 8, and 16 weeks, the test sites were excised and analyzed by histopathology and proteomics.
RESULTS
RESULTS
Extracellular matrix had a minimal foreign body response. HA had a good volume effect at the early stage but the volume retention rate was lower than CaHA in the long term. CaHA could stimulate neo-collagen formation.
CONCLUSION
CONCLUSIONS
This study has proven the effectiveness and safety of these fillers and could provide clinical guidance for the plastic surgeon.
Substances chimiques
Durapatite
91D9GV0Z28
Biocompatible Materials
0
Hyaluronic Acid
9004-61-9
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2685-2691Informations de copyright
© 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
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