Flares in IIMs and the timeline following COVID-19 vaccination: a combined analysis of the COVAD-1 and -2 surveys.
COVID-19 vaccines
disease exacerbation
idiopathic inflammatory myopathies
patient-reported outcomes
Journal
Rheumatology (Oxford, England)
ISSN: 1462-0332
Titre abrégé: Rheumatology (Oxford)
Pays: England
ID NLM: 100883501
Informations de publication
Date de publication:
04 Jan 2024
04 Jan 2024
Historique:
received:
12
01
2023
accepted:
14
04
2023
medline:
5
1
2024
pubmed:
21
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
Disease flares in the post-coronavirus disease 2019 (COVID-19) vaccination period represent a prominent concern, though risk factors are poorly understood. We studied these flares among patients with idiopathic inflammatory myopathies (IIMs) and other autoimmune rheumatic diseases (AIRDs). The COVAD-1 and -2 global surveys were circulated in early 2021 and 2022, respectively, and we captured demographics, comorbidities, AIRDs details, COVID-19 infection history and vaccination details. Flares of IIMs were defined as (a) patient self-reported, (b) immunosuppression (IS) denoted, (c) clinical sign directed and (d) with >7.9-point minimal clinically significant improvement difference worsening of Patient-Reported Outcomes Measurement Information System (PROMIS) PROMISPF10a score. Risk factors of flares were analysed using regression models. Of 15 165 total respondents, 1278 IIMs (age 63 years, 70.3% female, 80.8% Caucasians) and 3453 AIRDs were included. Flares of IIM were seen in 9.6%, 12.7%, 8.7% and 19.6% patients by definitions (a) to (d), respectively, with a median time to flare of 71.5 (10.7-235) days, similar to AIRDs. Patients with active IIMs pre-vaccination (OR 1.2; 95% CI 1.03, 1.6, P = 0.025) were prone to flares, while those receiving rituximab (OR 0.3; 95% CI 0.1, 0.7, P = 0.010) and AZA (OR 0.3, 95% CI 0.1, 0.8, P = 0.016) were at lower risk. Female gender and comorbidities predisposed to flares requiring changes in IS. Asthma (OR 1.62; 95% CI 1.05, 2.50, P = 0.028) and higher pain visual analogue score (OR 1.19; 95% CI 1.11, 1.27, P < 0.001) were associated with disparity between self-reported and IS-denoted flares. A diagnosis of IIMs confers an equal risk of flares in the post-COVID-19 vaccination period to AIRDs, with active disease, female gender and comorbidities conferring a higher risk. Disparity between patient- and physician-reported outcomes represents a future avenue for exploration.
Identifiants
pubmed: 37084267
pii: 7135840
doi: 10.1093/rheumatology/kead180
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-139Subventions
Organisme : Versus Arthritis
ID : 21992
Pays : United Kingdom
Investigateurs
Sinan Kardes
(S)
Laura Andreoli
(L)
Daniele Lini
(D)
Karen Screiber
(K)
Melinda Nagy Vince
(MN)
Yogesh Preet Singh
(YP)
Rajiv Ranjan
(R)
Avinash Jain
(A)
Sapan C Pandya
(SC)
Rakesh Kumar Pilania
(RK)
Aman Sharma
(A)
M Manesh Manoj
(M)
Vikas Gupta
(V)
Chengappa G Kavadichanda
(CG)
Pradeepta Sekhar Patro
(PS)
Sajal Ajmani
(S)
Sanat Phatak
(S)
Rudra Prosad Goswami
(RP)
Abhra Chandra Chowdhury
(AC)
Ashish Jacob Mathew
(AJ)
Padnamabha Shenoy
(P)
Ajay Asranna
(A)
Keerthi Talari Bommakanti
(KT)
Anuj Shukla
(A)
Arunkumar R Pande
(AR)
Kunal Chandwar
(K)
Akanksha Ghodke
(A)
Hiya Boro
(H)
Zoha Zahid Fazal
(ZZ)
Döndü Üsküdar Cansu
(DÜ)
Reşit Yıldırım
(R)
Armen Yuri Gasparyan
(AY)
Nicoletta Del Papa
(N)
Gianluca Sambataro
(G)
Atzeni Fabiola
(A)
Marcello Govoni
(M)
Simone Parisi
(S)
Elena Bartoloni Bocci
(EB)
Gian Domenico Sebastiani
(GD)
Enrico Fusaro
(E)
Marco Sebastiani
(M)
Luca Quartuccio
(L)
Franco Franceschini
(F)
Pier Paolo Sainaghi
(PP)
Giovanni Orsolini
(G)
Rossella De Angelis
(R)
Maria Giovanna Danielli
(MG)
Vincenzo Venerito
(V)
Silvia Grignaschi
(S)
Alessandro Giollo
(A)
Alessia Alluno
(A)
Florenzo Ioannone
(F)
Marco Fornaro
(M)
Lisa S Traboco
(LS)
Suryo Anggoro Kusumo Wibowo
(SAK)
Jesús Loarce-Martos
(J)
Sergio Prieto-González
(S)
Raquel Aranega Gonzalez
(RA)
Akira Yoshida
(A)
Ran Nakashima
(R)
Shinji Sato
(S)
Naoki Kimura
(N)
Yuko Kaneko
(Y)
Takahisa Gono
(T)
Stylianos Tomaras
(S)
Fabian Nikolai Proft
(FN)
Marie-Therese Holzer
(MT)
Margarita Aleksandrovna Gromova
(MA)
Or Aharonov
(O)
Zoltán Griger
(Z)
Ihsane Hmamouchi
(I)
Imane El Bouchti
(I)
Zineb Baba
(Z)
Margherita Giannini
(M)
François Maurier
(F)
Julien Campagne
(J)
Alain Meyer
(A)
Daman Langguth
(D)
Vidya Limaye
(V)
Merrilee Needham
(M)
Nilesh Srivastav
(N)
Marie Hudson
(M)
Océane Landon-Cardinal
(O)
Wilmer Gerardo Rojas Zuleta
(WGR)
Álvaro Arbeláez
(Á)
Javier Cajas
(J)
José António Pereira Silva
(JAP)
João Eurico Fonseca
(JE)
Olena Zimba
(O)
Doskaliuk Bohdana
(D)
Uyi Ima-Edomwonyi
(U)
Ibukunoluwa Dedeke
(I)
Emorinken Airenakho
(E)
Nwankwo Henry Madu
(NH)
Abubakar Yerima
(A)
Hakeem Olaosebikan
(H)
A Becky
(A)
Oruma Devi Koussougbo
(OD)
Elisa Palalane
(E)
Ho So
(H)
Manuel Francisco Ugarte-Gil
(MF)
Lyn Chinchay
(L)
José Proaño Bernaola
(JP)
Victorio Pimentel
(V)
Hanan Mohammed Fathi
(HM)
Reem Hamdy A Mohammed
(RHA)
Ghita Harifi
(G)
Yurilís Fuentes-Silva
(Y)
Karoll Cabriza
(K)
Jonathan Losanto
(J)
Nelly Colaman
(N)
Antonio Cachafeiro-Vilar
(A)
Generoso Guerra Bautista
(GG)
Enrique Julio Giraldo Ho
(EJG)
Raúl González
(R)
Lilith Stange Nunez
(LS)
M Cristian Vergara
(M)
Jossiell Then Báez
(JT)
Hugo Alonzo
(H)
Carlos Benito Santiago Pastelin
(CBS)
Rodrigo García Salinas
(RG)
Alejandro Quiñónez Obiols
(AQ)
Nilmo Chávez
(N)
Andrea Bran Ordóñez
(AB)
Gil Alberto Reyes Llerena
(GAR)
Radames Sierra-Zorita
(R)
Dina Arrieta
(D)
Eduardo Romero Hidalgo
(ER)
Ricardo Saenz
(R)
M Idania Escalante
(M)
Wendy Calapaqui
(W)
Ivonne Quezada
(I)
Gabriela Arredondo
(G)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.