Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium.
Drug-resistant epilepsy
Epilepsy surgery
Neuromodulation
Pediatric epilepsy
Responsive neurostimulation
Journal
Pediatric neurology
ISSN: 1873-5150
Titre abrégé: Pediatr Neurol
Pays: United States
ID NLM: 8508183
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
16
10
2022
revised:
22
01
2023
accepted:
02
03
2023
medline:
22
5
2023
pubmed:
22
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
Responsive neurostimulation (RNS), a closed-loop intracranial electrical stimulation system, is a palliative surgical option for patients with drug-resistant epilepsy (DRE). RNS is approved by the US Food and Drug Administration for patients aged ≥18 years with pharmacoresistant partial seizures. The published experience of RNS in children is limited. This is a combined prospective and retrospective study of patients aged ≤18 years undergoing RNS placement. Patients were identified from the multicenter Pediatric Epilepsy Research Consortium Surgery Registry from January 2018 to December 2021, and additional data relevant to this study were retrospectively collected and analyzed. Fifty-six patients received RNS during the study period. The mean age at implantation was 14.9 years; the mean duration of epilepsy, 8.1 years; and the mean number of previously trialed antiseizure medications, 4.2. Five patients (9%) previously trialed dietary therapy, and 19 patients (34%) underwent prior surgery. Most patients (70%) underwent invasive electroencephalography evaluation before RNS implantation. Complications occurred in three patients (5.3%) including malpositioned leads or transient weakness. Follow-up (mean 11.7 months) was available for 55 patients (one lost), and four were seizure-free with RNS off. Outcome analysis of stimulation efficacy was available for 51 patients: 33 patients (65%) were responders (≥50% reduction in seizure frequency), including five patients (10%) who were seizure free at follow-up. For young patients with focal DRE who are not candidates for surgical resection, neuromodulation should be considered. Although RNS is off-label for patients aged <18 years, this multicenter study suggests that it is a safe and effective palliative option for children with focal DRE.
Sections du résumé
BACKGROUND
Responsive neurostimulation (RNS), a closed-loop intracranial electrical stimulation system, is a palliative surgical option for patients with drug-resistant epilepsy (DRE). RNS is approved by the US Food and Drug Administration for patients aged ≥18 years with pharmacoresistant partial seizures. The published experience of RNS in children is limited.
METHODS
This is a combined prospective and retrospective study of patients aged ≤18 years undergoing RNS placement. Patients were identified from the multicenter Pediatric Epilepsy Research Consortium Surgery Registry from January 2018 to December 2021, and additional data relevant to this study were retrospectively collected and analyzed.
RESULTS
Fifty-six patients received RNS during the study period. The mean age at implantation was 14.9 years; the mean duration of epilepsy, 8.1 years; and the mean number of previously trialed antiseizure medications, 4.2. Five patients (9%) previously trialed dietary therapy, and 19 patients (34%) underwent prior surgery. Most patients (70%) underwent invasive electroencephalography evaluation before RNS implantation. Complications occurred in three patients (5.3%) including malpositioned leads or transient weakness. Follow-up (mean 11.7 months) was available for 55 patients (one lost), and four were seizure-free with RNS off. Outcome analysis of stimulation efficacy was available for 51 patients: 33 patients (65%) were responders (≥50% reduction in seizure frequency), including five patients (10%) who were seizure free at follow-up.
CONCLUSIONS
For young patients with focal DRE who are not candidates for surgical resection, neuromodulation should be considered. Although RNS is off-label for patients aged <18 years, this multicenter study suggests that it is a safe and effective palliative option for children with focal DRE.
Identifiants
pubmed: 37084698
pii: S0887-8994(23)00075-9
doi: 10.1016/j.pediatrneurol.2023.03.001
pii:
doi:
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-112Investigateurs
M Scott Perry
(MS)
Adam Ostendorf
(A)
Lily Wong-Kisiel
(L)
Erin Fedak Romanowski
(EF)
Nancy McNamara
(N)
Priyamvada Tatachar
(P)
Dewi Depositario-Cabacar
(D)
William D Gaillard
(WD)
Chima Oluigbo
(C)
Jennifer Koop
(J)
Rene Andrade-Machado
(R)
Pradeep Javarayee
(P)
Allyson L Alexander
(AL)
Krista Eschbach
(K)
Joffre Olaya
(J)
Daniel Shrey
(D)
Rani K Singh
(RK)
Zachary Grinspan
(Z)
Srishti Nangia
(S)
Samir Karia
(S)
Cemal Karakas
(C)
Jeffrey Bolton
(J)
Michael Ciliberto
(M)
Kurtis Auguste
(K)
Ernesto Gonzalez-Giraldo
(E)
Adam Numis
(A)
Joseph Sullivan
(J)
Jason Coryell
(J)
Satya Gedela
(S)
Jason Hauptman
(J)
Shilpa B Reddy
(SB)
Michael J McCormack
(MJ)
Chad M Manuel
(CM)
Debopam Samanta
(D)
Dallas Armstrong
(D)
Ahmad Marashly
(A)
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.