Intermediate and long-term exposure to air pollution and temperature and the extracellular microRNA profile of participants in the normative aging study (NAS).
Air pollution
Ambient temperature
Nitrogen dioxide
Ozone
Particulate matter
microRNA
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
15 07 2023
15 07 2023
Historique:
received:
01
02
2023
revised:
27
03
2023
accepted:
18
04
2023
pmc-release:
15
07
2024
medline:
22
5
2023
pubmed:
22
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
The molecular effects of intermediate and long-term exposure to air pollution and temperature, such as those on extracellular microRNA (ex-miRNA) are not well understood but may have clinical consequences. To assess the association between exposure to ambient air pollution and temperature and ex-miRNA profiles. Our study population consisted of 734 participants in the Normative Aging Study (NAS) between 1999 and 2015. We used high-resolution models to estimate four-week, eight-week, twelve-week, six-month, and one-year moving averages of PM We found 151 significant associations between levels of PM Our results show that intermediate and long-term exposure to all our exposures of interest were associated with changes in the ex-miRNA profile of study participants. Further studies on environmental risk factors and ex-miRNAs are warranted.
Sections du résumé
BACKGROUND
The molecular effects of intermediate and long-term exposure to air pollution and temperature, such as those on extracellular microRNA (ex-miRNA) are not well understood but may have clinical consequences.
OBJECTIVES
To assess the association between exposure to ambient air pollution and temperature and ex-miRNA profiles.
METHODS
Our study population consisted of 734 participants in the Normative Aging Study (NAS) between 1999 and 2015. We used high-resolution models to estimate four-week, eight-week, twelve-week, six-month, and one-year moving averages of PM
RESULTS
We found 151 significant associations between levels of PM
CONCLUSION
Our results show that intermediate and long-term exposure to all our exposures of interest were associated with changes in the ex-miRNA profile of study participants. Further studies on environmental risk factors and ex-miRNAs are warranted.
Identifiants
pubmed: 37084943
pii: S0013-9351(23)00741-7
doi: 10.1016/j.envres.2023.115949
pmc: PMC10335853
mid: NIHMS1912493
pii:
doi:
Substances chimiques
Air Pollutants
0
Nitrogen Dioxide
S7G510RUBH
Particulate Matter
0
nas
64706-31-6
MicroRNAs
0
Ozone
66H7ZZK23N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
115949Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES027747
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 ES999999
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Joel D Schwartz reports financial support was provided by National Institute of Environmental Health Sciences by grant R01ES027747. Joel D Schwartz reports a relationship with US Department of Justice that includes: paid expert testimony. Feiby L. Nassan is a current employee and a shareholder of Biogen, Cambridge, MA. The original work on this study at Harvard T. H. Chan School of Public Health (HSPH), however, pre-dated the current employment. This manuscript does not mention any Biogen products or any of the disease states that Biogen is actively doing research in (to the coauthor's knowledge).
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