Design of a Bilateral Disulfurating Reagent for Unsymmetrical Polysulfidation.

Alkyl Halides Disulfurating Reagent Metal-Free Unsymmetrical Disulfides β-SS Elimination

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
19 Jun 2023
Historique:
received: 26 02 2023
medline: 12 6 2023
pubmed: 22 4 2023
entrez: 21 04 2023
Statut: ppublish

Résumé

In this study, we designed a bilateral disulfurating reagent via S-S motif "snip and stitch" processes, allowing diverse functional groups to be bridged via S-S bonds. The reagent is readily synthesized in high yield using a one-step reaction from easily available starting materials and is air-stable. With this reagent, diverse electrophiles including inactivated alkyl Cl/Br/I/OMs and benzyl chloride were sequentially installed on either side of the S-S motif. Natural products, agrochemicals, and pharmaceuticals can be successively cross-linked with S-S bonds. Notably, the disulfurating reagent can be used in cyclic disulfide synthesis. At last, some desired products of this work showed good antibacterial activities, which could be employed as novel candidates to control plant pathogenic bacteria.

Identifiants

pubmed: 37085461
doi: 10.1002/anie.202302861
doi:

Substances chimiques

Indicators and Reagents 0
Disulfides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202302861

Subventions

Organisme : National Natural Science Foundation of China
ID : 22101005
Organisme : National Key Research and Development Program of China
ID : 2021YFD1700104
Organisme : Natural Science Foundation of Anhui Province
ID : 1908085QB87
Organisme : Key R & D projects of Anhui Province
ID : 202104a06020008
Organisme : Excellent Youth Program of Anhui Province
ID : 2022AH030095

Informations de copyright

© 2023 Wiley-VCH GmbH.

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Auteurs

Qingqiang Tian (Q)

Key Laboratory of Agri-Food Safety of Anhui Province, School of Resources and Environment,Anhui Agricultural University, Hefei, Anhui, 230036, China.

Yahui Li (Y)

Key Laboratory of Agri-Food Safety of Anhui Province, School of Resources and Environment,Anhui Agricultural University, Hefei, Anhui, 230036, China.

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