The association between acetylsalicylic acid and subarachnoid haemorrhage: the Framingham Heart Study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 04 2023
21 04 2023
Historique:
received:
01
04
2022
accepted:
14
04
2023
medline:
25
4
2023
pubmed:
22
4
2023
entrez:
21
04
2023
Statut:
epublish
Résumé
Studies investigating the association between acetylsalicylic acid (ASA) use and spontaneous subarachnoid haemorrhage (SAH) in the general population have produced conflicting results. The aim of this study is to clarify the relationship between SAH and ASA. We included all participants who reported on ASA use during interim examinations of the Framingham Heart Study Cohorts. Using Cox proportional-hazards regression modelling, we estimated the hazard ratio (HR) associated with ASA use. 7692 participants were included in this study. There were 30 cases of SAH during follow up, with an estimated incidence of 10.0 per 100,000 person- years (CI 6.90-14.15). Univariate analysis showed no association between regular ASA use and SAH (HR, 0.33 [0.08-1.41]; p = 0.14). This was similar when accounting for smoking (HR, 0.35 [0.08-1.51]; p = 0.16). Using a large longitudinal dataset from the Framingham Heart Study, we observed some evidence suggesting fewer SAH in those participants taking regular ASA. However, multivariate statistical analysis showed no significant association between ASA use and SAH. Due to the low incidence of SAH in the general population, the absolute number of SAH events was low and it remains uncertain if a significant effect would become apparent with more follow up.
Identifiants
pubmed: 37085588
doi: 10.1038/s41598-023-33570-9
pii: 10.1038/s41598-023-33570-9
pmc: PMC10121705
doi:
Substances chimiques
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6533Subventions
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
Références
Am J Epidemiol. 1979 Sep;110(3):281-90
pubmed: 474565
Stroke. 1993 Nov;24(11):1649-54
pubmed: 8236337
JAMA Neurol. 2019 May 1;76(5):588-597
pubmed: 30659573
Neurology. 2018 Sep 18;91(12):e1175-e1181
pubmed: 30135253
Stroke. 2017 May;48(5):1210-1217
pubmed: 28341753
Ann Intern Med. 2016 Jun 21;164(12):826-35
pubmed: 27064261
Stroke. 2015 Aug;46(8):2368-400
pubmed: 26089327
Am J Public Health Nations Health. 1951 Mar;41(3):279-81
pubmed: 14819398
Neurology. 2017 Nov 28;89(22):2280-2287
pubmed: 29093065
Br J Clin Pharmacol. 1979 Feb;7(2):139-47
pubmed: 367413
Nature. 1985 Nov 14-20;318(6042):186-8
pubmed: 3903519
J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1365-72
pubmed: 17470467
J Cereb Blood Flow Metab. 2012 Sep;32(9):1659-76
pubmed: 22781330
Neurology. 2021 Jan 5;96(1):e19-e29
pubmed: 33055274
Lancet Neurol. 2011 Jul;10(7):626-36
pubmed: 21641282
Neurology. 2013 Aug 6;81(6):559-65
pubmed: 23843467
Neurosurgery. 2018 Jul 1;83(1):43-52
pubmed: 28973585
Eur J Neurol. 2006 Oct;13(10):1098-105
pubmed: 16987162
Stroke. 2011 Nov;42(11):3156-62
pubmed: 21980208
Thromb Haemost. 2015 Nov;114(5):1064-75
pubmed: 26202836
World Neurosurg. 2020 Apr;136:e132-e140
pubmed: 31857268
Neurology. 1993 Apr;43(4):712-8
pubmed: 8469328
World Neurosurg. 2020 Jun;138:299-308
pubmed: 32165345
Int J Stroke. 2022 Mar;17(3):341-353
pubmed: 33705214
Stroke. 2004 Sep;35(9):2059-63
pubmed: 15272133
Am J Pathol. 2010 Dec;177(6):3224-32
pubmed: 20971742
World Neurosurg. 2014 Dec;82(6):1127-30
pubmed: 23548847
Stroke. 2013 Sep;44(9):2422-6
pubmed: 23813986
Clin Neurol Neurosurg. 2021 Jan;200:106320
pubmed: 33268193
Am J Med. 2006 Aug;119(8):624-38
pubmed: 16887404
Neurology. 2013 Aug 6;81(6):566-74
pubmed: 23843464
J Thromb Haemost. 2010 Jul;8(7):1468-74
pubmed: 20345728
Stroke. 1999 Sep;30(9):1764-71
pubmed: 10471421