Changes in the gut microbiome in the first two years of life predicted the temperament in toddlers.
Cohort
Gut microbiome
Gut microbiota
Temperament
Toddlers
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 07 2023
15 07 2023
Historique:
received:
02
11
2022
revised:
26
03
2023
accepted:
16
04
2023
medline:
16
5
2023
pubmed:
23
4
2023
entrez:
22
04
2023
Statut:
ppublish
Résumé
Temperament has been shown to be associated with the change of gut microbiome. There were no longitudinal studies to explore the role of gut microbiome changes in the development of temperament in toddlers. This study used longitudinal cohort to investigate the associations between changes in gut microbiome and temperament in toddlers in the first two years of life. Linear regression analysis and microbiome multivariate association with linear models were used to investigate the associations between the gut microbiome and toddlers' temperament. In total, 41 toddlers were analyzed. This study found both Shannon and Chao-1 indices at birth were negatively correlated with the sadness dimension; the higher the Shannon and Chao-1 indices at 6 months, the lower the surgency/extraversion dimension scores; the higher the Shannon and Chao-1 indices at 2 years of ages, the lower the cuddliness dimension scores. After adjusting for covariates, beta diversity at birth was strongly associated with the negative affectivity dimension; beta diversity at 1 year of age was strongly associated with the activity level dimension; and beta diversity at 2 years of age was strongly associated with the discomfort and soothability dimension. Compared to Bifidobacterium cluster, this study also found Bacteroides cluster was associated with lower negative affectivity and its sub-dimensions frustration and sadness scores in toddlers. Generalizability of the results remains to be determined. Results of this study confirmed the associations between changes in the gut microbiome diversity and composition in the first two years of life and toddlers' temperament.
Sections du résumé
BACKGROUND
Temperament has been shown to be associated with the change of gut microbiome. There were no longitudinal studies to explore the role of gut microbiome changes in the development of temperament in toddlers.
METHODS
This study used longitudinal cohort to investigate the associations between changes in gut microbiome and temperament in toddlers in the first two years of life. Linear regression analysis and microbiome multivariate association with linear models were used to investigate the associations between the gut microbiome and toddlers' temperament.
RESULTS
In total, 41 toddlers were analyzed. This study found both Shannon and Chao-1 indices at birth were negatively correlated with the sadness dimension; the higher the Shannon and Chao-1 indices at 6 months, the lower the surgency/extraversion dimension scores; the higher the Shannon and Chao-1 indices at 2 years of ages, the lower the cuddliness dimension scores. After adjusting for covariates, beta diversity at birth was strongly associated with the negative affectivity dimension; beta diversity at 1 year of age was strongly associated with the activity level dimension; and beta diversity at 2 years of age was strongly associated with the discomfort and soothability dimension. Compared to Bifidobacterium cluster, this study also found Bacteroides cluster was associated with lower negative affectivity and its sub-dimensions frustration and sadness scores in toddlers.
LIMITATIONS
Generalizability of the results remains to be determined.
CONCLUSION
Results of this study confirmed the associations between changes in the gut microbiome diversity and composition in the first two years of life and toddlers' temperament.
Identifiants
pubmed: 37086808
pii: S0165-0327(23)00537-2
doi: 10.1016/j.jad.2023.04.073
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
342-352Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors have no conflicts of interest to declare that are relevant to the content of this study.