Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation.

Mice Animals Mice, Transgenic Amyloid beta-Peptides / metabolism Alzheimer Disease / pathology Amyloid beta-Protein Precursor / genetics Cognition Mutation / genetics Disease Models, Animal
Alzheimer’s disease Amyloid-β Aβ Osaka Cerebral connectivity Memory Synapses

Journal

Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673

Informations de publication

Date de publication:
22 04 2023
Historique:
received: 17 02 2023
accepted: 25 03 2023
medline: 25 4 2023
pubmed: 23 4 2023
entrez: 22 04 2023
Statut: epublish

Résumé

Alzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly correlated with cognitive decline. Intracerebral infusion of well-defined Aβ seeds from non-mutated Aβ

Identifiants

DOI: 10.1186/s40478-023-01559-0 PMID: 37087498 PMC: PMC10122826
pubmed: 37087498
doi: 10.1186/s40478-023-01559-0
pii: 10.1186/s40478-023-01559-0
pmc: PMC10122826
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

66

Informations de copyright

© 2023. The Author(s).

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Auteurs

Marina Célestine (M)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
ORCID: 0000-0001-5845-9779

Muriel Jacquier-Sarlin (M)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, 38000, Grenoble, France.

Eve Borel (E)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, 38000, Grenoble, France.

Fanny Petit (F)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.

Jean-Baptiste Perot (JB)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.

Anne-Sophie Hérard (AS)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.

Luc Bousset (L)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.

Alain Buisson (A)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, 38000, Grenoble, France.
ORCID: 0000-0002-4281-7911

Marc Dhenain (M)

Laboratoire Des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-Aux-Roses, France. Marc.Dhenain@cnrs.fr.
Commissariat À L'Energie Atomique Et Aux Énergies Alternatives (CEA), Direction de La Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. Marc.Dhenain@cnrs.fr.
ORCID: 0000-0001-8804-4101

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Eucaryotes › Animaux › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Long term worsening of amyloid pathology,...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Long term worsening of amyloid pathology,...