Gut microbiota dependant trimethylamine N-oxide and hypertension.
TMAO
gut
hypertension
mechanisms
microbiota
trimethylamine N-oxide
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
10
2022
accepted:
31
03
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
The human gut microbiota environment is constantly changing and some specific changes influence the host's metabolic, immune, and neuroendocrine functions. Emerging evidence of the gut microbiota's role in the development of cardiovascular disease (CVD) including hypertension is remarkable. There is evidence showing that alterations in the gut microbiota and especially the gut-dependant metabolite trimethylamine N-oxide is associated with hypertension. However, there is a scarcity of literature addressing the role of trimethylamine N-oxide in hypertension pathogenesis. In this review, we discuss the impact of the gut microbiota and gut microbiota dependant trimethylamine N-oxide in the pathogenesis of hypertension. We present evidence from both human and animal studies and further discuss new insights relating to potential therapies for managing hypertension by altering the gut microbiota.
Identifiants
pubmed: 37089429
doi: 10.3389/fphys.2023.1075641
pii: 1075641
pmc: PMC10118022
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1075641Informations de copyright
Copyright © 2023 Mutengo, Masenga, Mweemba, Mutale and Kirabo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
World J Gastroenterol. 2015 Aug 7;21(29):8787-803
pubmed: 26269668
Circ Res. 2015 Jan 30;116(3):448-55
pubmed: 25599331
Hypertension. 2021 Aug;78(2):499-511
pubmed: 33966451
Nat Microbiol. 2019 Jan;4(1):155-163
pubmed: 30455469
Lipids Health Dis. 2018 Dec 19;17(1):286
pubmed: 30567573
Antioxidants (Basel). 2021 Dec 30;11(1):
pubmed: 35052589
Elife. 2020 Jun 08;9:
pubmed: 32510330
BMC Med. 2014 Jul 24;12:112
pubmed: 25055810
Biol Bull. 1999 Feb;196(1):18-25
pubmed: 25575382
Can J Cardiol. 2012 May;28(3):288-95
pubmed: 22445098
Nature. 2017 Nov 30;551(7682):585-589
pubmed: 29143823
PLoS One. 2020 Jan 15;15(1):e0227482
pubmed: 31940332
Acta Physiol (Oxf). 2019 Sep;227(1):e13285
pubmed: 31004464
Curr Obes Rep. 2022 Dec;11(4):287-304
pubmed: 36178601
J Transl Med. 2022 Aug 18;20(1):374
pubmed: 35982495
Nutrients. 2020 Sep 29;12(10):
pubmed: 33003455
Nat Rev Cardiol. 2019 Mar;16(3):137-154
pubmed: 30410105
Biol Sex Differ. 2019 Apr 25;10(1):22
pubmed: 31023366
Clin Res Hepatol Gastroenterol. 2018 Apr;42(2):110-117
pubmed: 29102544
Hypertension. 2022 Oct;79(10):2138-2147
pubmed: 35862173
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27377678
Dig Dis. 2013;31(3-4):278-85
pubmed: 24246975
Nutrients. 2021 Jun 19;13(6):
pubmed: 34205336
Bone. 2012 Feb;50(2):437-43
pubmed: 21816244
Plant Foods Hum Nutr. 2018 Mar;73(1):1-6
pubmed: 29230708
Eur Heart J. 2019 Feb 14;40(7):583-594
pubmed: 30535398
Cell. 2012 Mar 16;148(6):1258-70
pubmed: 22424233
Nutr Res Rev. 2021 Jun;34(1):125-146
pubmed: 32718365
Hypertension. 2015 Jun;65(6):1331-40
pubmed: 25870193
Hypertension. 2021 Jan;77(1):190-192
pubmed: 33296247
Gastroenterol Clin North Am. 2005 Sep;34(3):361-82, vii
pubmed: 16084302
Hypertension. 2012 Dec;60(6):1560-7
pubmed: 23108657
Kidney360. 2022 Jun 27;3(9):1620-1629
pubmed: 36245645
Gut Microbes. 2021 Jan-Dec;13(1):1-21
pubmed: 33722164
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23
pubmed: 15505215
ESC Heart Fail. 2020 Dec;7(6):3497-3504
pubmed: 33089967
Eur J Nutr. 2018 Feb;57(1):1-24
pubmed: 28393285
Atherosclerosis. 2013 Mar;227(1):51-7
pubmed: 23305793
Circ Res. 2018 Oct 26;123(10):1164-1176
pubmed: 30359185
Int J Mol Sci. 2022 Jun 28;23(13):
pubmed: 35806159
Intern Emerg Med. 2021 Jan;16(1):201-207
pubmed: 32779113
Microbiome. 2017 May 15;5(1):54
pubmed: 28506279
Clin Res Cardiol. 2022 Jun;111(6):692-704
pubmed: 35220448
Microbiome. 2017 Feb 1;5(1):14
pubmed: 28143587
Biomarkers. 2018 May - Jun;23(4):380-385
pubmed: 29363331
Kidney Blood Press Res. 2021;46(4):421-432
pubmed: 34233325
Circ Res. 2021 Apr 2;128(7):934-950
pubmed: 33793332
J Nutr. 2016 Feb;146(2):283-9
pubmed: 26674761
JCI Insight. 2019 Jun 4;5:
pubmed: 31162138
Sci Rep. 2019 Mar 12;9(1):4249
pubmed: 30862856
Eur J Nutr. 2021 Oct;60(7):3567-3584
pubmed: 33533968
Nature. 2010 Mar 4;464(7285):59-65
pubmed: 20203603
Pharmacol Res. 2013 Mar;69(1):52-60
pubmed: 23147033
Annu Rev Microbiol. 2011;65:411-29
pubmed: 21682646
Cell Metab. 2019 Dec 3;30(6):1141-1151.e5
pubmed: 31543404
Front Pharmacol. 2022 Aug 12;13:929262
pubmed: 36034781
Exp Biol Med (Maywood). 2020 Jan;245(2):166-175
pubmed: 31948289
Am J Respir Cell Mol Biol. 2022 Apr;66(4):452-460
pubmed: 35100519
Crit Care Clin. 2020 Apr;36(2):307-321
pubmed: 32172815
APMIS. 2020 May;128(5):353-366
pubmed: 32108960
Gut Microbes. 2021 Jan-Dec;13(1):1-24
pubmed: 33764858
Physiol Genomics. 2017 Feb 1;49(2):96-104
pubmed: 28011881
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
Prostaglandins Other Lipid Mediat. 2018 Nov;139:48-53
pubmed: 30278231
Int J Mol Sci. 2021 Nov 01;22(21):
pubmed: 34769294
Curr Hypertens Rev. 2015;11(2):132-42
pubmed: 26022210
Nutrients. 2020 Dec 22;13(1):
pubmed: 33375042
Front Pharmacol. 2019 Nov 19;10:1360
pubmed: 31803054
Nutrients. 2021 Apr 01;13(4):
pubmed: 33915885
Physiol Genomics. 2015 Oct;47(10):479-87
pubmed: 26242933
Eur Heart J. 2013 Apr;34(16):1204-14
pubmed: 23144048
Nutrients. 2018 Oct 01;10(10):
pubmed: 30275434
JACC Cardiovasc Imaging. 2021 Aug;14(8):1548-1557
pubmed: 33865770
Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):63-70
pubmed: 27833015
Am J Hypertens. 2004 Aug;17(8):701-6
pubmed: 15288885
J Tradit Complement Med. 2021 Sep 22;13(2):107-118
pubmed: 36970453
Mediators Inflamm. 2020 Feb 17;2020:4634172
pubmed: 32148438
Toxins (Basel). 2019 Nov 01;11(11):
pubmed: 31683880
Microorganisms. 2020 Oct 01;8(10):
pubmed: 33019531
OMICS. 2014 Jul;18(7):402-14
pubmed: 24785449
Lab Invest. 2019 Mar;99(3):346-357
pubmed: 30068915
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
J Inflamm (Lond). 2022 Oct 4;19(1):14
pubmed: 36195874
Mol Cell. 2012 Nov 30;48(4):612-26
pubmed: 23063526
Toxicol Lett. 2017 Feb 5;267:32-38
pubmed: 28049038
J Nutr Biochem. 2016 Jan;27:27-31
pubmed: 26376027
BMJ. 2018 Jun 13;361:k2179
pubmed: 29899036
Front Cell Infect Microbiol. 2022 May 26;12:896309
pubmed: 35719363
EXCLI J. 2021 Feb 11;20:301-319
pubmed: 33746664
N Engl J Med. 2018 Jun 21;378(25):e34
pubmed: 29897866
Circ Res. 2017 Mar 31;120(7):1183-1196
pubmed: 28360349
Mol Nutr Food Res. 2021 Jun;65(11):e2001116
pubmed: 33547712
Endocrinology. 2014 Nov;155(11):4296-304
pubmed: 25167221
Surg Clin North Am. 2011 Aug;91(4):771-85, viii
pubmed: 21787967
PLoS One. 2019 Sep 11;14(9):e0206484
pubmed: 31509535
Evol Bioinform Online. 2016 May 12;12(Suppl 1):5-16
pubmed: 27199545
J Microbiol Biotechnol. 2020 Oct 28;30(10):1510-1515
pubmed: 32627760
PLoS One. 2016 Apr 06;11(4):e0152044
pubmed: 27050757
Adv Nutr. 2020 Jan 1;11(1):66-76
pubmed: 31269204
Sci Transl Med. 2014 Mar 12;6(227):227ra36
pubmed: 24622516
Hypertens Res. 2022 Feb;45(2):246-253
pubmed: 34887530
Hypertension. 2014 Nov;64(5):1131-40
pubmed: 25069665
J Biol Chem. 2015 Aug 28;290(35):21732-40
pubmed: 26187464
Front Physiol. 2022 Apr 19;13:861659
pubmed: 35514347
J Am Heart Assoc. 2017 Sep 4;6(9):
pubmed: 28871042
Hypertension. 2022 Aug;79(8):1591-1601
pubmed: 35538603
Cell Physiol Biochem. 2017;44(1):152-162
pubmed: 29130962
mBio. 2015 Mar 17;6(2):e02481
pubmed: 25784704
Annu Rev Nutr. 2017 Aug 21;37:157-181
pubmed: 28715991
Circ Cardiovasc Interv. 2019 Jan;12(1):e007281
pubmed: 30599768
Nutr Metab Cardiovasc Dis. 2021 Jul 22;31(8):2458-2470
pubmed: 34090773
BMC Microbiol. 2021 Feb 12;21(1):44
pubmed: 33579191
Redox Biol. 2021 Oct;46:102115
pubmed: 34474396
Expert Rev Mol Med. 2016 Nov 23;18:e19
pubmed: 27876109
Hypertension. 2019 Sep;74(3):555-563
pubmed: 31280647
Nutr Rev. 2016 Oct;74(10):645-58
pubmed: 27566757
J Am Heart Assoc. 2016 Jun 10;5(6):
pubmed: 27287696
Front Med (Lausanne). 2022 Jan 19;8:742394
pubmed: 35127738
Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G697-711
pubmed: 24072680
Front Cardiovasc Med. 2022 Jul 22;9:922441
pubmed: 35935641
J Chem Neuroanat. 2004 Sep;28(1-2):79-92
pubmed: 15363493
Hypertension. 2018 Dec;72(6):1328-1336
pubmed: 30571224
Arch Cardiol Mex. 2016 Apr-Jun;86(2):163-9
pubmed: 26774359
Int J Mol Sci. 2018 Oct 19;19(10):
pubmed: 30347638
Nature. 2013 Aug 29;500(7464):541-6
pubmed: 23985870
Eur Heart J Open. 2022 Mar 29;2(5):oeac021
pubmed: 36071697
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5
pubmed: 17699621
Front Immunol. 2014 Nov 28;5:614
pubmed: 25506346
J Am Heart Assoc. 2016 Feb 22;5(2):
pubmed: 26903003
Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1173-H1182
pubmed: 31585045
Sci Rep. 2019 Oct 30;9(1):15580
pubmed: 31666590
Toxins (Basel). 2016 Nov 08;8(11):
pubmed: 27834801
Nutrients. 2020 May 07;12(5):
pubmed: 32392758
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Mol Nutr Food Res. 2020 Mar;64(6):e1900616
pubmed: 31953983
Curr Hypertens Rep. 2020 Sep 3;22(10):79
pubmed: 32880753
Curr Opin Nephrol Hypertens. 2015 Sep;24(5):403-9
pubmed: 26125644
Hypertension. 2014 Oct;64(4):897-903
pubmed: 25047574
Nat Rev Mol Cell Biol. 2020 Aug;21(8):421-438
pubmed: 32457508
Nutrients. 2018 Dec 13;10(12):
pubmed: 30551613
JACC Basic Transl Sci. 2018 Jan 10;3(1):54-66
pubmed: 30062194
Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1805-H1820
pubmed: 30265149
ISME J. 2010 Feb;4(2):232-41
pubmed: 19865183
Transl Res. 2021 Feb;228:109-125
pubmed: 32841736
Physiol Rev. 2010 Jul;90(3):859-904
pubmed: 20664075
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Maturitas. 2017 Sep;103:45-53
pubmed: 28778332
Nat Med. 2018 Sep;24(9):1407-1417
pubmed: 30082863
J Clin Endocrinol Metab. 2017 Nov 1;102(11):4124-4135
pubmed: 28938457
PLoS One. 2009;4(1):e4170
pubmed: 19137072
Biomed Pharmacother. 2021 Feb;134:111156
pubmed: 33401080
Indian Heart J. 2018 Jul - Aug;70(4):556-564
pubmed: 30170653
Front Nutr. 2021 Jun 07;8:693412
pubmed: 34164427
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Nutrition. 2018 Oct;54:33-39
pubmed: 29705499
Circulation. 2017 Mar 7;135(10):964-977
pubmed: 27927713
Heart. 2016 Jun 1;102(11):841-8
pubmed: 26869641
Mol Nutr Food Res. 2018 Oct;62(19):e1800298
pubmed: 30028078
J Am Heart Assoc. 2016 Oct 21;5(10):
pubmed: 27792658
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2341-9
pubmed: 21071698
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
Hypertension. 2021 Jun;77(6):e53-e55
pubmed: 33866801
N Engl J Med. 2013 Apr 25;368(17):1575-84
pubmed: 23614584
J Hypertens. 2016 Jan;34(1):156-62
pubmed: 26630218
Front Cardiovasc Med. 2021 Nov 23;8:723886
pubmed: 34888358
J Am Heart Assoc. 2021 Sep 7;10(17):e020646
pubmed: 34398665