Analysis of hemopexin plasma levels in patients with age-related macular degeneration.

Humans Hemopexin / genetics Macular Degeneration / genetics Genotype Complement Factor H / genetics Transcription Factors / genetics Polymorphism, Single Nucleotide / genetics

Journal

Molecular vision
ISSN: 1090-0535
Titre abrégé: Mol Vis
Pays: United States
ID NLM: 9605351

Informations de publication

Date de publication:
2022
Historique:
received: 08 05 2021
accepted: 29 12 2022
medline: 25 4 2023
pubmed: 24 4 2023
entrez: 24 04 2023
Statut: epublish

Résumé

A protein quantitative trait locus (pQTL) analysis recently revealed a strong association between hemopexin (HPX) levels and genetic variants at the complement factor H ( HPX levels were quantified in 200 advanced AMD cases and 200 controls using an enzyme-linked immunosorbent assay and compared between the two groups. Furthermore, HPX levels were analyzed per genotype group of three HPX-associated variants (rs61818956, rs10494745, and rs10801582) and four AMD-associated variants (rs794362 [proxy for rs187328863], rs570618, rs10922109, and rs61818924 [proxy for rs61818925]) at the HPX levels were similar in the control group compared with the AMD group. The three variants at the In this study, HPX levels were not associated with AMD or AMD-associated variants at the

Identifiants

PMID: 37089696 PMC: PMC10115365
pubmed: 37089696
pii: 45
pmc: PMC10115365

Substances chimiques

Hemopexin 9013-71-2
Complement Factor H 80295-65-4
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

536-543

Informations de copyright

Copyright © 2022 Molecular Vision.

Références

Asia Pac J Ophthalmol (Phila). 2017 Nov-Dec;6(6):493-497
pubmed: 28906084
Hum Mol Genet. 2013 Dec 1;22(23):4857-69
pubmed: 23873044
Nat Genet. 2016 Feb;48(2):134-43
pubmed: 26691988
Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):18
pubmed: 32176267
Blood. 2013 Jul 11;122(2):282-92
pubmed: 23692858
Trends Mol Med. 2016 Mar;22(3):200-213
pubmed: 26875449
Nat Commun. 2017 Feb 27;8:14357
pubmed: 28240269
DNA Cell Biol. 2002 Apr;21(4):297-306
pubmed: 12042069
FEBS Lett. 1999 Dec 3;462(3):345-52
pubmed: 10622723
JCI Insight. 2018 Jun 21;3(12):
pubmed: 29925688
Biopreserv Biobank. 2015 Oct;13(5):307-8
pubmed: 26484569
Nat Commun. 2020 Feb 7;11(1):778
pubmed: 32034129
JAMA. 2020 Aug 25;324(8):794-795
pubmed: 32780786

Auteurs

Susette Lauwen (S)

Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Bjorn Bakker (B)

Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Eiko K de Jong (EK)

Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Sascha Fauser (S)

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.

Carel B Hoyng (CB)

Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Dirk J Lefeber (DJ)

Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Translational Metabolic Laboratory, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Anneke I den Hollander (AI)

Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Hémopexine › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Dégénérescence maculaire › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › bêta-Globulines › Facteur H du complément › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Analysis of hemopexin plasma levels in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Analysis of hemopexin plasma levels in...