Epidemiological and Molecular Characteristics of
Klebsiella pneumoniae
blaKPC-2
blaNDM-1
carbapenem resistance
illumina sequencing
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
12
2022
accepted:
01
04
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Carbapenem-resistant In this study, Multiplex polymerase chain reaction (PCR) was performed to detect the carbapenem-resistant genes, and the broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of antibacterial drugs. The transferability of carbapenem-resistant phenotypes was examined using filter mating assays. Overall, we used Illumina sequencing to evaluate the epidemiological and molecular characteristics of All strains exhibited resistance to carbapenems and other antibiotics. However, they were still susceptible to polymyxin E. Among them, 18 isolates were positive for These findings suggested that ST11-KL64 CRKP strains are major threats in terms of nosocomial infections in this hospital. Hence, new strategies should be urgently developed to monitor, diagnose, and treat this high-risk CRKP clone.
Identifiants
pubmed: 37090038
doi: 10.2147/IDR.S400138
pii: 400138
pmc: PMC10120834
doi:
Banques de données
figshare
['10.6084/m9.figshare.21360120']
Types de publication
Journal Article
Langues
eng
Pagination
2247-2258Informations de copyright
© 2023 Rong et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this work.
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