Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
04 Dec 2023
04 Dec 2023
Historique:
pubmed:
24
4
2023
medline:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response. The trafficking and cellular tropism of the Spike protein
Identifiants
pubmed: 37090605
doi: 10.1101/2023.03.13.532446
pmc: PMC10120727
pii:
doi:
Types de publication
Preprint
Langues
eng