Modulation of NK cell activation by exogenous calcium from alginate dressings
NK cell cytotoxicity
calcium alginate wound dressings
calcium ions
natural killer cells
wound healing
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
01
2023
accepted:
16
03
2023
medline:
25
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Natural Killer (NK) cells participate in the defense against infection by killing pathogens and infected cells and secreting immuno-modulatory cytokines. Defects in NK cell activity have been reported in obese, diabetic, and elderly patients that are at high risk of developing infected chronic wounds. Calcium alginate dressings are indicated for the debridement during the inflammatory phase of healing. Since calcium ions are major activators of NK cells, we hypothesized that these dressings could enhance NK functions, as investigated
Identifiants
pubmed: 37090742
doi: 10.3389/fimmu.2023.1141047
pmc: PMC10117844
doi:
Substances chimiques
Calcium
SY7Q814VUP
Alginates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141047Informations de copyright
Copyright © 2023 Adib, Boy, Serror, Dulphy, des Courtils, Duciel, Boccara, Mimoun, Samardzic, Bagot, Bensussan and Michel.
Déclaration de conflit d'intérêts
This work was supported by Laboratoires Brothier, Nanterre, France. CC, LD and MS are employed by Laboratoires Brothier, Nanterre, France. There are marketed products to declare. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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