The quest for vaccine-induced immune correlates of protection against tuberculosis.
BCG
M72/AS01E
correlates of protection
systems vaccinology
tuberculosis
Journal
Vaccine insights
ISSN: 2752-5422
Titre abrégé: Vaccine Insights
Pays: England
ID NLM: 9918557476006676
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Immunization strategies against tuberculosis (TB) that confer better protection than neonatal vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to control the epidemic, but clinical development is hampered by a lack of established immune correlates of protection (CoPs). Two phase 2b clinical trials offer the first opportunity to discover human CoPs against TB. Adolescent BCG re-vaccination showed partial protection against
Identifiants
pubmed: 37091190
doi: 10.18609/vac/2022.027
pmc: PMC10117634
mid: NIHMS1865255
doi:
Types de publication
Journal Article
Langues
eng
Pagination
165-181Subventions
Organisme : Bill & Melinda Gates Foundation
ID : INV-004813
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-027499
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI054165
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068635
Pays : United States
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