Targeted plasma proteomics identifies MICA and IL1R1 proteins associated with HIV-1 reservoir size.
Health sciences
Proteomics
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Apr 2023
21 Apr 2023
Historique:
received:
02
08
2022
revised:
18
01
2023
accepted:
18
03
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
HIV-1 reservoir shows high variability in size and activity among virally suppressed individuals. Differences in the size of the viral reservoir may relate to differences in plasma protein concentrations. We tested whether plasma protein expression levels are associated with levels of cell-associated (CA) HIV-1 DNA and RNA in 211 virally suppressed people living with HIV (PLHIV). Plasma concentrations of FOLR1, IL1R1, MICA, and FETUB showed a positive association with CA HIV-1 RNA and DNA. Moreover, SNPs in close proximity to
Identifiants
pubmed: 37091231
doi: 10.1016/j.isci.2023.106486
pii: S2589-0042(23)00563-1
pmc: PMC10113782
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106486Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4
pubmed: 28407485
Virology. 2017 Oct;510:9-21
pubmed: 28689087
Front Immunol. 2021 Apr 19;12:661990
pubmed: 33953724
Immunity. 2012 Sep 21;37(3):426-40
pubmed: 22999948
J Infect Dis. 2014 Dec 15;210(12):1946-50
pubmed: 24939907
J Virol. 2014 Sep 1;88(17):10056-65
pubmed: 24965451
Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3704-3710
pubmed: 32029589
Genome Biol. 2017 Apr 27;18(1):76
pubmed: 28449694
J Immunol. 2019 Jan 1;202(1):228-238
pubmed: 30530590
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
PLoS Pathog. 2018 Feb 22;14(2):e1006856
pubmed: 29470552
JCI Insight. 2018 May 17;3(10):
pubmed: 29769442
J Virol. 2013 Aug;87(16):9148-58
pubmed: 23760244
J Intern Med. 2009 Jan;265(1):29-42
pubmed: 19093958
BMC Med. 2021 Nov 16;19(1):282
pubmed: 34781942
PLoS One. 2014 Apr 22;9(4):e95192
pubmed: 24755770
J Infect Dis. 2020 Feb 18;221(5):744-755
pubmed: 31796951
Nat Med. 2016 Sep;22(9):1043-9
pubmed: 27500724
Lipids. 2016 Jun;51(6):655-76
pubmed: 27117865
J Clin Virol. 2012 Jan;53(1):29-32
pubmed: 22019250
Nature. 2017 Mar 23;543(7646):564-567
pubmed: 28297712
Trends Biochem Sci. 2002 Sep;27(9):474-82
pubmed: 12217523
Nature. 2002 Oct 17;419(6908):734-8
pubmed: 12384702
Cell Rep Med. 2021 May 18;2(5):100287
pubmed: 33969320
Annu Rev Immunol. 2011;29:295-317
pubmed: 21219175
N Engl J Med. 1998 Mar 26;338(13):853-60
pubmed: 9516219
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Nat Rev Immunol. 2003 Oct;3(10):781-90
pubmed: 14523385
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Science. 2010 Dec 10;330(6010):1551-7
pubmed: 21051598
J Antimicrob Chemother. 2019 Oct 1;74(10):3030-3034
pubmed: 31314108
JCI Insight. 2021 Apr 8;6(7):
pubmed: 33630761
Front Immunol. 2019 Jun 20;10:1412
pubmed: 31281320
Nat Med. 2003 Jun;9(6):727-8
pubmed: 12754504
PLoS Pathog. 2016 Jul 14;12(7):e1005761
pubmed: 27415008
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Nat Med. 2009 Aug;15(8):893-900
pubmed: 19543283
PLoS Pathog. 2008 Feb 8;4(2):e30
pubmed: 18266471
J Pediatr. 2005 Mar;146(3):423-5
pubmed: 15756234
Science. 1999 Jul 30;285(5428):727-9
pubmed: 10426993
Nat Commun. 2021 Jun 29;12(1):3922
pubmed: 34188039
Adv Nutr. 2012 Jan;3(1):21-38
pubmed: 22332098
Cell. 2016 Nov 3;167(4):894-896
pubmed: 27814519
Clin Invest Med. 2018 Mar 27;41(1):E25-E30
pubmed: 29603688
Int J Med Sci. 2020 Jan 14;17(2):182-190
pubmed: 32038102
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15109-14
pubmed: 10611346
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7708-13
pubmed: 12799463
J Immunol. 2005 Jul 15;175(2):720-9
pubmed: 16002667
AIDS. 2010 Nov 27;24(18):2803-8
pubmed: 20962613
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Cell Metab. 2015 Dec 1;22(6):1078-89
pubmed: 26603189
FASEB J. 2013 Jun;27(6):2440-50
pubmed: 23395909
F1000Prime Rep. 2014 Nov 04;6:97
pubmed: 25580251
Virology. 2010 Oct 10;406(1):12-20
pubmed: 20667578
Cancer Immunol Res. 2015 Jun;3(6):575-82
pubmed: 26041808