Gender-gap in randomized clinical trials reporting mortality in the perioperative setting and critical care: 20 years behind the scenes.
Critically ill patient
Diversity
Equity
Gender gap
Inclusion
RCT
Journal
Contemporary clinical trials communications
ISSN: 2451-8654
Titre abrégé: Contemp Clin Trials Commun
Pays: Netherlands
ID NLM: 101671157
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
18
10
2022
revised:
06
03
2023
accepted:
13
03
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Women researchers might experience obstacles in academic environments and might be underrepresented in the authorship of articles published in peer-reviewed journals. This is a cross-sectional analysis of female-led RCTs describing all interventions reducing mortality in critically ill and perioperative patients from 1981 to December 31, 2020. We searched PubMed/MEDLINE and EMBASE with the keywords RCTs and mortality. The gender of the first author was extracted and descriptive analysis was performed including the year of publication, impact factor, country of the first author, and methodological aspects. We analyzed 340 RCTs, of which 42 (12%) were led by female researchers. The presence of women increased from 8% (14/172) until 2010 up to 17% (28/168) in 2010 and beyond. The United States, the United Kingdom, and Brazil were the main countries of origin of female researchers. Women authors conducted mainly single-center and single-nation studies as compared to male authors. The median impact factor of the target journal was 6 (3-27) in women vs. 7 (3-28) in men, with a p-value of 0.67; In the last 40 years, only one out of eight RCTs had a woman as the first author but the presence of women increased up to 17% by 2010 and beyond. The impact factor of publication target journals was high and not different between genders.
Sections du résumé
Background
UNASSIGNED
Women researchers might experience obstacles in academic environments and might be underrepresented in the authorship of articles published in peer-reviewed journals.
Material and Methods
UNASSIGNED
This is a cross-sectional analysis of female-led RCTs describing all interventions reducing mortality in critically ill and perioperative patients from 1981 to December 31, 2020. We searched PubMed/MEDLINE and EMBASE with the keywords RCTs and mortality. The gender of the first author was extracted and descriptive analysis was performed including the year of publication, impact factor, country of the first author, and methodological aspects.
Results
UNASSIGNED
We analyzed 340 RCTs, of which 42 (12%) were led by female researchers. The presence of women increased from 8% (14/172) until 2010 up to 17% (28/168) in 2010 and beyond. The United States, the United Kingdom, and Brazil were the main countries of origin of female researchers. Women authors conducted mainly single-center and single-nation studies as compared to male authors. The median impact factor of the target journal was 6 (3-27) in women vs. 7 (3-28) in men, with a p-value of 0.67;
Conclusion
UNASSIGNED
In the last 40 years, only one out of eight RCTs had a woman as the first author but the presence of women increased up to 17% by 2010 and beyond. The impact factor of publication target journals was high and not different between genders.
Identifiants
pubmed: 37091504
doi: 10.1016/j.conctc.2023.101117
pii: S2451-8654(23)00063-7
pmc: PMC10119706
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
101117Informations de copyright
©2023PublishedbyElsevierInc.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Arch Intern Med. 2008 Mar 10;168(5):544-8
pubmed: 18332302
JAMA Oncol. 2019 Oct 1;5(10):1503-1504
pubmed: 31318379
Ann Intern Med. 2014 Mar 4;160(5):344-53
pubmed: 24737273
BMJ. 2016 Mar 02;352:i847
pubmed: 26935100
Br J Anaesth. 2020 Mar;124(3):e171-e177
pubmed: 31980158
Microbiol Mol Biol Rev. 2019 Jul 17;83(3):
pubmed: 31315903
Ann Glob Health. 2018 Nov 05;84(4):743-752
pubmed: 30779525
Br J Anaesth. 2020 Mar;124(3):e63-e69
pubmed: 31980155
J Cardiothorac Vasc Anesth. 2019 Dec;33(12):3229-3234
pubmed: 31412981
Crit Care Med. 2019 Apr;47(4):e286-e291
pubmed: 30855331
Circulation. 2018 Feb 20;137(8):880-882
pubmed: 29459476
JAMA Netw Open. 2019 Nov 1;2(11):e1915165
pubmed: 31722028
PLoS One. 2013 Oct 30;8(10):e79147
pubmed: 24205372
JAMA. 2015 Sep 15;314(11):1175-7
pubmed: 26372589
Lancet. 2008 Jul 12;372(9633):139-144
pubmed: 18582931
Br J Anaesth. 2020 Mar;124(3):e160-e170
pubmed: 32005515
Bone Jt Open. 2021 Oct;2(10):893-899
pubmed: 34698532
J Cardiothorac Vasc Anesth. 2019 Mar;33(3):593-599
pubmed: 30638921
BMJ. 2019 Dec 16;367:l6573
pubmed: 31843745
Ann Intern Med. 2007 Oct 16;147(8):573-7
pubmed: 17938396
Gend Med. 2011 Dec;8(6):378-87
pubmed: 22153882
JAMA. 2015 Sep 15;314(11):1149-58
pubmed: 26372584
BMC Med Educ. 2015 Apr 02;15:67
pubmed: 25889674
Can J Anaesth. 2021 Oct;68(10):1485-1496
pubmed: 34159567
BMJ Glob Health. 2019 Mar 4;4(2):e001047
pubmed: 30899571
Acad Med. 2020 Jul;95(7):1043-1049
pubmed: 31625994
Plast Reconstr Surg. 2019 Oct;144(4):1010-1016
pubmed: 31568321
JAMA Ophthalmol. 2021 Oct 1;139(10):1078-1079
pubmed: 34383021
Am J Cardiol. 2022 Jan 15;163:138-139
pubmed: 34736720
JAMA Oncol. 2019 Jan 1;5(1):15-16
pubmed: 30452515
JAMA Netw Open. 2021 Jul 1;4(7):e2114509
pubmed: 34213560