SARM1 detection in myelinating glia:
SARM1
Schwann cell
mouse
myelination
oligodendrocyte
zebrafish
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
02
2023
accepted:
14
03
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1 has been extensively studied in neurons, it remains unknown whether SARM1 is present and functional in myelinating glia? This is an important question to address. Firstly, to identify whether SARM1 dysfunction in other cell types in the nervous system may contribute to neuropathology in SARM1 dependent diseases? Secondly, to ascertain whether therapies altering SARM1 function may have unintended deleterious impacts on PNS or CNS myelination? Surprisingly, we find that oligodendrocytes express
Identifiants
pubmed: 37091921
doi: 10.3389/fncel.2023.1158388
pmc: PMC10113485
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1158388Subventions
Organisme : Wellcome Trust
ID : 206634/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210904/Z/18/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Fazal, Mutschler, Chen, Turmaine, Chen, Hsueh, Ibañez-Grau, Loreto, Casillas-Bajo, Cabedo, Franklin, Barker, Monk, Steventon, Coleman, Gomez-Sanchez and Arthur-Farraj.
Déclaration de conflit d'intérêts
MC was a consultant for Nura Bio. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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