JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex.

acetyl-CoA acetylation epigenetics gene expression lipogenesis lipolysis

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2023
Historique:
received: 30 12 2022
accepted: 29 03 2023
medline: 24 4 2023
pubmed: 24 4 2023
entrez: 24 04 2023
Statut: epublish

Résumé

The multisubunit NuA4/TIP60 complex is a lysine acetyltransferase, chromatin modifying factor and gene co-activator involved in diverse biological processes. The past decade has seen a growing appreciation for its role as a metabolic effector and modulator. However, molecular insights are scarce and often contradictory, underscoring the need for further mechanistic investigation. A particularly exciting route emerged with the recent identification of a novel subunit, JAZF1, which has been extensively linked to metabolic homeostasis. This review summarizes the major findings implicating NuA4/TIP60 in metabolism, especially in light of JAZF1 as part of the complex.

Identifiants

pubmed: 37091973
doi: 10.3389/fcell.2023.1134268
pii: 1134268
pmc: PMC10119425
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1134268

Informations de copyright

Copyright © 2023 Mameri and Côté.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Amel Mameri (A)

St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada.

Jacques Côté (J)

St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada.

Classifications MeSH