Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs.
Gfi1
HSC
differentiation
dose-dependent
engraftment
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
01
2022
accepted:
06
03
2023
medline:
24
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. Serial transplantation of
Identifiants
pubmed: 37091981
doi: 10.3389/fcell.2023.866847
pii: 866847
pmc: PMC10113925
doi:
Types de publication
Journal Article
Langues
eng
Pagination
866847Informations de copyright
Copyright © 2023 Xie, Patnana, Frank, Schütte, Al-Matary, Künstner, Busch, Ahmed, Liu, Engel, Dührsen, Rosenbauer, Von Bubnoff, Lenz and Khandanpour.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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