Tick-borne encephalitis.
Journal
Current opinion in infectious diseases
ISSN: 1473-6527
Titre abrégé: Curr Opin Infect Dis
Pays: United States
ID NLM: 8809878
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
medline:
28
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Tick-borne encephalitis continues to be one of the most significant causes of viral encephalitis in Europe and Asia. This review will focus on recent developments in the epidemiology, pathogenesis and therapeutic approaches related to infection with tick-borne encephalitis virus. There is a growing consensus that tick-borne encephalitis viruses are increasing in geographical range, with countries previously free of disease reporting detection of both human cases and presence of virus within indigenous tick populations. The drivers for this are multifactorial but underpinned by human-mediated climate change. Recent developments in pathogenesis have focussed on the intracellular response to infection, particularly in different cell types within the central nervous system (CNS) that are revealing the array of cellular networks triggered by infection. This in turn highlights the need for small molecule therapeutics, such as nucleoside analogues, that can enter the CNS, and the intracellular environment, to inhibit virus replication following neuroinvasion. Based on continued epidemiological surveillance, tick-borne encephalitis viruses will increasingly affect human populations in Europe and Asia. Much of the research highlighted in this review demonstrates incremental advances in our understanding of these viruses. However, more is required if effective prevention and treatment of this devastating encephalitic viruses are to be realized.
Identifiants
pubmed: 37093044
doi: 10.1097/QCO.0000000000000924
pii: 00001432-202306000-00009
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
198-202Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Fares W, Dachraoui K, Cherni S, et al. Tick-borne encephalitis virus in Ixodes ricinus (Acari: Ixodidae) ticks, Tunisia. Ticks Tick Borne Dis 2021; 12:101606.
Krow-Lucal ER, Lindsey NP, Fischer M, Hills SL. Powassan virus disease in the United States. Vector Borne Zoonotic Dis 2018; 18:286–290.
Moutailler S, Popovici I, Devillers E, et al. Diversity of viruses in Ixodes ricinus , and characterization of a neurotropic strain of Eyach virus. New Microbes New Infect 2016; 11:71–81.
Dilcher M, Hasib L, Lechner M, et al. Genetic characterization of Tribeč virus and Kemerovo virus, two tick-transmitted human-pathogenic orbiviruses. Virology 2012; 423:68–76.
Tambo E, El-Dessouky AG. Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide. PLoS Negl Trop Dis 2018; 12:10–13.
Madani TA, Abuelzein EME. Alkhurmra hemorrhagic fever virus infection. Arch Virol 2021; 166:2357–2367.
Savage HM, Godsey MS, Panella NA, et al. Surveillance for tick-borne viruses near the location of a fatal human case of Bourban virus (Family Orthomyxovifidae: Genus Thogotovirus) in Eastern Kansas. J Med Entomol 2018; 55:701–705.
Brault AC, Savage HM, Duggal NK, et al. Heartland virus epidemiology, vector association, and disease potential. Viruses 2018; 10:1–17.
Lei XY, Liu MM, Jie X. Severe fever with thrombocytopenia syndrome and its pathogen SFTSV. Microbes Infect 2015; 17:149–154.
Martello E, Gillingham EL, Phalkey R, et al. Systematic review on the nonvectorial transmission of tick-borne encephalitis virus (TBEv). Ticks Tick Borne Dis 2022; 13:102028.
Gonzalez G, Bournez L, Moraes RA, et al. A One-Health approach to investigating an outbreak of alimentary tick-borne encephalitis in a nonendemic area in France (Ain, Eastern France): a longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation. Front Microbiol 2022; 13:863725.
Kohlmaier B, Schnwintzger NA, Sagmeister MG, et al. Clinical characteristics of patients with a tick-borne encephalitis (TBE): a European multicentre study from 2010 to 2017. Microorganisms 2021; 9:9071420.
Kunze M, Banović P, Bogović P, et al. Recommendations to improve tick-borne encephalitis surveillance and vaccine uptake in Europe. Microorganisms 2022; 10:1283.
Heinze DM, Gould EA, Forrester NL. Revisiting the clinal concept of evolution and dispersal for the tick-borne flaviviruses by using phylogenetic and biogeographic analyses. J Virol 2012; 86:8663–8671.
Valarcher JF, Hägglund S, Juremalm M, et al. Tick-borne encephalitis. Rev Sci Tech 2015; 34:453–466.
Kovalev SY, Mukhachava TA. Reconsidering the classification of tick-borne encephalitis virus within the Siberian subtype gives new insights into it evolutionary history. Infect Genet Evol 2017; 55:159–165.
Dai X, Shang G, Lu S, Xu J. A new subtype of eastern tick-borne encephalitis virus discovered in Qinghai-Tibet Plateau, China. Emerg Microb Infect 2018; 7:74.
Hvidsten D, Frafjord K, Gray JS, et al. The distribution limit of the common tick, Ixodes ricinus and some associated pathogens in north-west Europe. Tick Tick Borne Dis 2020; 11:101388.
Jahfari S, de Vries A, Rijks JM, et al. Tick-borne encephalitis virus in ticks and roe deer, the Netherlands. Emerg Infect Dis 2017; 23:1028–2030.
Holding M, Dowall SD, Medlock JM, et al. Tick-borne encephalitis virus, United Kingdom. Emerg Infect Dis 2020; 26:90–96.
Lang D, Chitimia-Dobler L, Bestehorn-WIllmann M, et al. The emergence and dynamics of tick-borne encephalitis virus in a new endemic region in Southern Germany. Microorganisms 2022; 10:2125.
Casati Pagani S, Frigerio Malossa S, Klaus C, et al. First detection of TBE virus in ticks and sero-reactivity in goats in a nonendemic region in the southern part of Switzerland (Canton of Ticino). Ticks Tick Borne Dis 2019; 10:868–874.
Alfano N, Tagliapietra V, Rosso F, et al. Tick-borne encephalitis foci in northeast Italy revealed by combined virus detection in ticks, serosurvey on goats and human cases. Emerg Microbes Infect 2020; 9:474–484.
Velay S, Solis M, Kack-Kack W, et al. A new hot spot for tick-borne encephalitis (TBE): A marked increase of TBE cases in France in 2016. Tick Tick Borne Dis 2018; 9:120–125.
Thorin C, Rigaud E, Capek I, et al. Séroprévalence de la borréliose de Lyme et de l’encéphalite à tiques chez des professionnels exposés dans le Grande Est de la France. Médecine Mal Infect 2008; 38:533–542.
Bournez L, Umhang G, Boucher J-M, et al. Exposure of wild ungulates to the Usutu and tick-borne encephalitis viruses in France in 2009-2014: evidence of undetected flavivirus circulation a decade ago. Viruses 2019; 12:10.
Garcia-Vozmediano A, Bellato A, Rossi L, et al. Circulation in a naïve area of the northwestern Alps, Italy. Life (Basel) 2022; 15:1888.
Jore S, Viliugrein H, Hofshagen M, et al. Multisource analysis reveals latitudinal and altitudinal shifts in range of Ixodes ricinus at its northern distribution limit. Parsit Vectors 2011; 4:84.
Blom K, Cuapio A, Sandberg JT, et al. Cell-mediated immune responses and immunopathogenesis of human tick-borne encephalitis virus-infection. Front Immunol 2018; 9:2174.
Lafaille FG, Ciancanelli MJ, Studer L, et al. Deciphering human cell-autonomous anti-HSV-1 immunity in the Central Nervous System. Front Immunol 2015; 6:208.
Fares M, Gorna K, Berry N, et al. Transcriptomic studies suggest a coincident role for apopotosis and pyroptosis but not for autophagic neuronal death in TBEV-infected human neuronal/glial cells. Viruses 2021; 13:2255.
Selinger M, Vĕchtová P, Tykalová H, et al. Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors. Comput Struct Biotechnol J 2022; 20:2759–2777.
Schultz JS, Sparks H, Beckham JD. Arboviral central nervous system infections. Curr Opin Infect Dis 2021; 34:264–271.
Eyer L, Svoboda P, Balvan J, et al. Broad-spectrum antiviral activity of 3’deoxy-3’-fluoroadenosine against emerging flaviviruses. Antimicrob Agents Chemother 2021; 65:e01522–e01520.
Eyer L, Seley-Radtke K, Ruzek D. New direction in the experimental therapy of tick-borne encephalitis. Antiviral Res 2022; 210:105504.
Zlobin VI, Pogodina VV, Kahl O. A brief history of the discovery of tick-borne encephalitis virus in the late 19302 (based on reminiscences of members of the expeditions, their colleagues, and relatives). Tick Tick Borne Dis 2017; 8:813–820.