Amebic encephalitis and meningoencephalitis: an update on epidemiology, diagnostic methods, and treatment.
Journal
Current opinion in infectious diseases
ISSN: 1473-6527
Titre abrégé: Curr Opin Infect Dis
Pays: United States
ID NLM: 8809878
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
medline:
28
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Free-living amebae (FLA) including Naegleria fowleri , Balamuthia mandrillaris , and Acanthamoeba species can cause rare, yet severe infections that are nearly always fatal. This review describes recent developments in epidemiology, diagnosis, and treatment of amebic meningoencephalitis. Despite similarities among the three pathogenic FLA, there are notable variations in disease presentations, routes of transmission, populations at risk, and outcomes for each. Recently, molecular diagnostic tools have been used to diagnose a greater number of FLA infections. Treatment regimens for FLA have historically relied on survivor reports; more data is needed about novel treatments, including nitroxoline. Research to identify new drugs and guide treatment regimens for amebic meningoencephalitis is lacking. However, improved diagnostic capabilities may lead to earlier diagnoses, allowing earlier treatment initiation and improved outcomes. Public health practitioners should continue to prioritize increasing awareness and providing education to clinicians, laboratorians, and the public about amebic infections.
Identifiants
pubmed: 37093056
doi: 10.1097/QCO.0000000000000923
pii: 00001432-202306000-00007
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-191Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Centers for Disease Control and Prevention. Free living amebic infections 2019. Available at: https://www.cdc.gov/dpdx/freelivingamebic/index.html . [Accessed 12 January 2023]
Centers for Disease Control and Prevention. Naegleria fowleri - primary amebic meningoencephalitis (PAM) - sources of infection & risk factors 2023. Available at: https://www.cdc.gov/parasites/naegleria/infection-sources.html . [Accessed 10 February 2023]
Cope JR, Landa J, Nethercut H, et al. The epidemiology and clinical features of Balamuthia mandrillaris disease in the United States, 1974–2016. Clin Infect Dis 2019; 68:1815–1822.
Haston JC, O’Laughlin K, Matteson K, et al. The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956–2020. Open Forum Infect Dis 2023; 10:ofac682.
Centers for Disease Control and Prevention. Naegleria fowleri - primary amebic meningoencephalitis (PAM) - Treatment 2022. Available at: https://www.cdc.gov/parasites/naegleria/treatment-hcp.html .
Gharpure R, Gleason M, Salah Z, et al. Geographic range of recreational water-associated primary amebic meningoencephalitis, United States, 1978–2018. Emerg Infect Dis 2021; 27:271–274.
Kemble SK, Lynfield R, DeVries AS, et al. Fatal Naegleria fowleri infection acquired in Minnesota: possible expanded range of a deadly thermophilic organism. Clin Infect Dis 2012; 54:805–809.
Salazar-Ardiles C, Asserella-Rebollo L, Andrade DC. Free-living amoebas in extreme environments: the true survival in our planet. Biomed Res Int 2022; 2022:2359883.
Mapili K, Rhoads WJ, Coughter M, et al. Occurrence of opportunistic pathogens in private wells after major flooding events: a four state molecular survey. Sci Total Environ 2022; 826:153901.
Miko S, Cope JR, Hlavsa MC, et al. Case of primary amebic meningoencephalitis associated with surfing at an artificial surf venue: environmental investigation. ACS ES&T Water 2023; https://pubs.acs.org/doi/pdf/10.1021/acsestwater.2c00592
doi: https://pubs.acs.org/doi/pdf/10.1021/acsestwater.2c00592
Centers for Disease Control and Prevention. Operation and Management of Splash Pads 2021. Available at: https://www.cdc.gov/healthywater/swimming/swimmers/splash-pad-operation-and-management.html . [Accessed 13 March 2023]
Centers for Disease Control and Prevention. The MAHC Current Edition. 2018. Available at: https://www.cdc.gov/mahc/editions/current.html . [Accessed 13 March 2023]
Centers for Disease Control and Prevention. Notes from the field: primary amebic meningoencephalitis associated with ritual nasal rinsing--St. Thomas, U. S. Virgin islands, 2012. MMWR Morb Mortal Wkly Rep 2013; 62:903.
Yoder JS, Straif-Bourgeois S, Roy SL, et al. Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water. Clin Infect Dis 2012; 55:e79–e85.
Gharpure R, Bliton J, Goodman A, et al. Epidemiology and clinical characteristics of primary amebic meningoencephalitis caused by Naegleria fowleri: a global review. Clin Infect Dis 2021; 73:e19–e27.
FDOH in Charlotte Advises Community on Naegleria Fowleri Infection [press release]. Florida Health - Charlotte County. 2023.
Cope JR, Roy S, Ali I. 865. Acanthamoeba disease associated with the practice of nasal rinsing in immunocompromised patients. Open Forum Infect Dis 2018; 5: (Suppl 1): S22.
Centers for Disease Control and Prevention. Sinus Rinsing for Health or Religious Practice 2017. Available at: https://www.cdc.gov/parasites/naegleria/sinus-rinsing.html . [Accessed 12 January 2023]
Ahmad Zamzuri MAI, Abd Majid FN, Mihat M, et al. Systematic review of brain-eating amoeba: a decade update. Int J Environ Res Public Health 2023; 20:3021.
Celik Y, Arslankoylu AE. A newborn with brain-eating ameba infection. J Trop Pediatr 2021; 67:fmaa100.
Tootla HD, Eley BS, Enslin JMN, et al. Balamuthia mandrillaris granulomatous amoebic encephalitis: the first African experience. J Pediatric Infect Dis Soc 2022; 11:578–581.
Saffioti C, Mesini A, Caorsi R, et al. Balamuthia mandrillaris infection: report of 1st autochthonous, fatal case in Italy. Eur J Clin Microbiol Infect Dis 2022; 41:685–687.
Tabassum S, Naeem A, Gill S, et al. Increasing cases of Naegleria fowleri during the time of COVID 19; an emerging concern of Pakistan. Int J Surg 2022; 105:106881.
Wang Q, Li J, Ji J, et al. A case of Naegleria fowleri related primary amoebic meningoencephalitis in China diagnosed by next-generation sequencing. BMC Infect Dis 2018; 18:349.
Leal Dos Santos D, Chaúque BJM, Virginio VG, et al. Occurrence of Naegleria fowleri and their implication for health - a look under the One Health approaches. Int J Hyg Environ Health 2022; 246:114053.
Stahl LM, Olson JB. Investigating the interactive effects of temperature, pH, and salinity on Naegleria fowleri persistence. J Eukaryot Microbiol 2023; e12964.
Krishnamoorthi S, Sharma C, Mewara A, Khurana S. Environmental water surveillance for free-living amoeba in North India. Indian J Med Microbiol 2022; 40:389–393.
Shahin A, Alarcon H, Brosky HN, et al. Occurrence of Naegleria fowleri and faecal indicators in sediments from Lake Pontchartrain, Louisiana. J Water Health 2022; 20:657–669.
Fabros MRL, Diesta XRS, Oronan JA, et al. Current report on the prevalence of free-living amoebae (FLA) in natural hot springs: a systematic review. J Water Health 2021; 19:563–574.
Xue J, Lamar FG, Zhang B, et al. Quantitative assessment of Naegleria fowleri and fecal indicator bacteria in brackish water of Lake Pontchartrain, Louisiana. Sci Total Environ 2018; 622-623:8–16.
Rao G, Kahler A, Voth-Gaeddert LE, et al. Microbial characterization, factors contributing to contamination, and household use of cistern water, U.S. Virgin Islands. ACS ES T Water 2022; 2:2634–2644.
Padua M, Masangkay FR, Alejandro GJD, Milanez GJ. Detection of Acanthamoeba spp. in groundwater sources in a rural area in the Philippines. J Water Health 2023; 21:138–146.
Gabr NS, Mohamed RM, Belal US, et al. Isolation and identification of pathogenic Acanthamoeba species from air conditioning systems, Egypt. Jpn J Infect Dis 2021; 74:180–186.
Karaman U, Koloren Z, Karanis P. Survey and first report of Acanthamoeba T4 genotype in natural spring water resources in the Black Sea, Turkey. J Water Health 2022; 20:193–204.
Eftekhari-Kenzerki R, Solhjoo K, Babaei Z, et al. High occurrence of Acanthamoeba spp. in the water samples of public swimming pools from Kerman Province, Iran. J Water Health 2021; 19:864–871.
Stockman LJ, Wright CJ, Visvesvara GS, et al. Prevalence of Acanthamoeba spp. and other free-living amoebae in household water, Ohio, USA–1990–1992. Parasitol Res 2011; 108:621–627.
Carnt NA, Subedi D, Lim AW, et al. Prevalence and seasonal variation of Acanthamoeba in domestic tap water in greater Sydney, Australia. Clin Exp Optom 2020; 103:782–786.
Guan Q, Alhuthali B, Mfarrej S, et al. Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis. J Travel Med 2022; 29:taab172.
Huang S, Liang X, Han Y, et al. A pediatric case of primary amoebic meningoencephalitis due to Naegleria fowleri diagnosed by next-generation sequencing of cerebrospinal fluid and blood samples. BMC Infect Dis 2021; 21:1251.
Xu C, Wu X, Tan M, et al. Subacute Balamuthia mandrillaris encephalitis in an immunocompetent patient diagnosed by next-generation sequencing. J Int Med Res 2022; 50:3000605221093217.
Peng L, Zhou Q, Wu Y, et al. A patient with granulomatous amoebic encephalitis caused by Balamuthia mandrillaris survived with two excisions and medication. BMC Infect Dis 2022; 22:54.
Yang Y, Hu X, Min L, et al. Lab Med 2020; 51:e20–e26.
Hirakata S, Sakiyama Y, Yoshimura A, et al. The application of shotgun metagenomics to the diagnosis of granulomatous amoebic encephalitis due to Balamuthia mandrillaris: a case report. BMC Neurol 2021; 21:392.
Zhou W, Ouyang Y, Zhang D, et al. Case report and literature review: bacterial meningoencephalitis or not? Naegleria fowleri related primary amoebic meningoencephalitis in China. Front Pediatr 2022; 10:785735.
Haston JC, Rostad CA, Jerris RC, et al. Prospective cohort study of next-generation sequencing as a diagnostic modality for unexplained encephalitis in children. J Pediatric Infect Dis Soc 2020; 9:326–333.
Wilson MR, Shanbhag NM, Reid MJ, et al. Diagnosing Balamuthia mandrillaris encephalitis with metagenomic deep sequencing. Ann Neurol 2015; 78:722–730.
Kalyatanda G, Rand K, Lindner MS, et al. Rapid, noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test. Open Forum Infect Dis 2020; 7:ofaa189.
Park SY, Chang EJ, Ledeboer N, et al. Plasma microbial cell-free DNA sequencing from over 15,000 patients identified a broad spectrum of pathogens. medRxiv 2023.
Laurie MT, White CV, Retallack H, et al. Functional assessment of 2,177 U.S. and international drugs identifies the quinoline nitroxoline as a potent amoebicidal agent against the pathogen Balamuthia mandrillaris. mBio 2018; 9:e02051-18.
Naber KG, Niggemann H, Stein G, Stein G. Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections. BMC Infect Dis 2014; 14:628.
Spottiswoode N, Pet D, Kim A, et al. Successful treatment of Balamuthia mandrillaris granulomatous amebic encephalitis with nitroxoline. Emerg Infect Dis 2023; 29:197–201.
Kangussu-Marcolino MM, Ehrenkaufer GM, Chen E, et al. Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. Int J Parasitol Drugs Drug Resist 2019; 11:80–94.