Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.
Alopecia areata
Hearing loss
Meta-analysis
Systematic review
Journal
Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
07
2022
accepted:
03
04
2023
medline:
7
8
2023
pubmed:
25
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL. We performed a systematic review and searched MEDLINE and Embase on July 25, 2022, for cross-sectional, case-control, or cohort studies that examined the association of AA with SNHL. The Newcastle-Ottawa Scale was used to evaluate their risk of bias. A random-effects model meta-analysis was performed to obtain the mean differences in frequency-specific hearing thresholds between AA patients and age-matched healthy controls and the pooled odds ratio for SNHL in relation to AA. We included 5 case-control studies and 1 cohort study, with none of them rated with high risk of biases. The meta-analysis showed AA patients had significantly higher mean differences in pure-tone hearing thresholds at 4,000 Hz and 12,000-12,500 Hz. The meta-analysis also found increased odds for SNHL among patients with AA (OR: 3.18; 95% CI: 2.06-4.89; I2 = 0%). AA is associated with an increase of SNHL, especially at high frequencies. Otologic consultation may be indicated if AA patients present with hearing loss or tinnitus.
Sections du résumé
BACKGROUND
BACKGROUND
Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL.
METHODS
METHODS
We performed a systematic review and searched MEDLINE and Embase on July 25, 2022, for cross-sectional, case-control, or cohort studies that examined the association of AA with SNHL. The Newcastle-Ottawa Scale was used to evaluate their risk of bias. A random-effects model meta-analysis was performed to obtain the mean differences in frequency-specific hearing thresholds between AA patients and age-matched healthy controls and the pooled odds ratio for SNHL in relation to AA.
RESULTS
RESULTS
We included 5 case-control studies and 1 cohort study, with none of them rated with high risk of biases. The meta-analysis showed AA patients had significantly higher mean differences in pure-tone hearing thresholds at 4,000 Hz and 12,000-12,500 Hz. The meta-analysis also found increased odds for SNHL among patients with AA (OR: 3.18; 95% CI: 2.06-4.89; I2 = 0%).
CONCLUSIONS
CONCLUSIONS
AA is associated with an increase of SNHL, especially at high frequencies. Otologic consultation may be indicated if AA patients present with hearing loss or tinnitus.
Identifiants
pubmed: 37094565
pii: 000530784
doi: 10.1159/000530784
pmc: PMC10407832
doi:
Types de publication
Systematic Review
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
523-532Informations de copyright
© 2023 The Author(s). Published by S. Karger AG, Basel.
Références
Ann Otol Rhinol Laryngol. 2011 Aug;120(8):523-8
pubmed: 21922976
J Am Acad Dermatol. 2018 Jan;78(1):1-12
pubmed: 29241771
J Invest Dermatol. 2001 Dec;117(6):1357-62
pubmed: 11886495
Mayo Clin Proc. 1995 Jul;70(7):628-33
pubmed: 7791384
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
Am J Pathol. 2007 Dec;171(6):1872-86
pubmed: 18055548
Dermatol Ther. 2011 May-Jun;24(3):348-54
pubmed: 21689244
Otol Neurotol. 2015 Mar;36(3):e99-100
pubmed: 25569367
Int J Clin Pract. 2021 May;75(5):e14040
pubmed: 33484073
J Am Acad Dermatol. 2021 Dec;85(6):1465-1472
pubmed: 33359081
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Audiol Neurootol. 2014;19(1):49-56
pubmed: 24335059
J Med Life. 2015;8 Spec Issue:43-6
pubmed: 26361510
Int J Audiol. 2014 Aug;53(8):531-45
pubmed: 24749665
J Investig Dermatol Symp Proc. 2001 Nov;6(1):95-8
pubmed: 11764294
Hear Res. 2009 Mar;249(1-2):1-14
pubmed: 19141317
J Invest Dermatol. 2008 May;128(5):1196-206
pubmed: 18160967
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Int Tinnitus J. 2021 Mar 01;25(1):76-86
pubmed: 34410084
JAMA Dermatol. 2020 Nov 1;156(11):1262-1264
pubmed: 32745180
Nat Med. 2014 Sep;20(9):1043-9
pubmed: 25129481
BMC Med. 2004 Aug 20;2:30
pubmed: 15320950
Ear Hear. 2020 Sep 22;42(3):565-573
pubmed: 33928924
J Allergy Clin Immunol. 2019 Dec;144(6):1478-1489
pubmed: 31606262
J Eur Acad Dermatol Venereol. 2022 Mar;36(3):373-379
pubmed: 34779053
G Ital Dermatol Venereol. 2014 Feb;149(1):25-45
pubmed: 24566564
Adv Otorhinolaryngol. 1990;45:203-5
pubmed: 2077891
Laryngoscope. 2006 Oct;116(10):1873-6
pubmed: 17003710
Exp Cell Res. 2004 Mar 10;294(1):60-7
pubmed: 14980501
J Eur Acad Dermatol Venereol. 2014 Aug;28(8):1045-8
pubmed: 24033465
Otol Neurotol. 2021 Mar 1;42(3):377-383
pubmed: 33196532
Br J Dermatol. 2006 Sep;155(3):515-21
pubmed: 16911275
J Am Acad Audiol. 2011 Jan;22(1):23-33
pubmed: 21419067
Br J Dermatol. 2018 Nov;179(5):1033-1048
pubmed: 29791718
Science. 1999 Jul 30;285(5428):727-9
pubmed: 10426993
Eur J Dermatol. 2004 Jan-Feb;14(1):33-6
pubmed: 14965793
Surv Ophthalmol. 2017 Jan - Feb;62(1):1-25
pubmed: 27241814
Pigment Cell Res. 1999 Dec;12(6):344-54
pubmed: 10614574
Clin Otolaryngol. 2018 Apr;43(2):705-710
pubmed: 29045013
J Family Med Prim Care. 2020 Jan 28;9(1):31-35
pubmed: 32110561
Arch Dermatol. 1992 Aug;128(8):1072-7
pubmed: 1497361
Int J Occup Med Environ Health. 2007;20(2):127-36
pubmed: 17638679
J Invest Dermatol. 1990 Jun;94(6):803-7
pubmed: 2355182
Annu Rev Immunol. 2009;27:363-91
pubmed: 19302045
N Engl J Med. 2012 Apr 19;366(16):1515-25
pubmed: 22512484
J Immunol. 1993 May 15;150(10):4478-85
pubmed: 7683320
Pigment Cell Res. 2007 Apr;20(2):134-9
pubmed: 17371440