Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort.
Diabetes Mellitus, Type 2
Evidence-Based Medicine
Risk Factors
Women's Health
Journal
BMJ open diabetes research & care
ISSN: 2052-4897
Titre abrégé: BMJ Open Diabetes Res Care
Pays: England
ID NLM: 101641391
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
03
10
2022
accepted:
18
02
2023
medline:
26
4
2023
pubmed:
25
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Type 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the contemporary cohort represented by the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). GRADE enrolled 5047 participants (1837 women, 3210 men) with T2DM on metformin monotherapy at baseline. The current report is a cross-sectional analysis of baseline data collected July 2013 to August 2017. Compared with men, women had a higher mean body mass index (BMI), greater prevalence of severe obesity (BMI≥40 kg/m This contemporary cohort demonstrates that women with T2DM continue to have a greater burden of cardiometabolic and socioeconomic risk factors than men, particularly younger women. Attention to these persisting disparities is needed to reduce the burden of CVD in women. ClinicalTrials.gov (NCT01794143).
Identifiants
pubmed: 37094945
pii: 11/2/e003159
doi: 10.1136/bmjdrc-2022-003159
pmc: PMC10151943
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT01794143']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002537
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072476
Pays : United States
Organisme : NIDDK NIH HHS
ID : U34 DK088043
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001108
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002489
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001409
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK119083
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000439
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001425
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001449
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK092926
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK098246
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Investigateurs
J P Crandall
(JP)
M D McKee
(MD)
S Behringer-Massera
(S)
J Brown-Friday
(J)
E Xhori
(E)
K Ballentine-Cargill
(K)
S Duran
(S)
H Estrella
(H)
S Gonzalez de la Torre
(S)
J Lukin
(J)
L S Phillips
(LS)
E Burgess
(E)
D Olson
(D)
M Rhee
(M)
P Wilson
(P)
T S Raines
(TS)
J Boers
(J)
J Costello
(J)
M Maher-Albertelli
(M)
R Mungara
(R)
L Savoye
(L)
C A White
(CA)
C Gullett
(C)
L Holloway
(L)
F Morehead
(F)
S Person
(S)
M Sibymon
(M)
S Tanukonda
(S)
C Adams
(C)
A Ross
(A)
A Balasubramanyam
(A)
R Gaba
(R)
E Gonzalez Hattery
(E)
A Ideozu
(A)
J Jimenez
(J)
G Montes
(G)
C Wright
(C)
P Hollander
(P)
E Roe
(E)
A Jackson
(A)
A Smiley
(A)
P Burt
(P)
L Estrada
(L)
K Chionh
(K)
F Ismail-Beigi
(F)
C Falck-Ytter
(C)
L Sayyed Kassem
(L)
A Sood
(A)
M Tiktin
(M)
T Kulow
(T)
C Newman
(C)
K A Stancil
(KA)
B Cramer
(B)
J Iacoboni
(J)
M V Kononets
(MV)
C Sanders
(C)
L Tucker
(L)
A Werner
(A)
A Maxwell
(A)
G McPhee
(G)
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(C)
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(J)
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(CR)
K Evans Kreider
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(CN)
K J Mather
(KJ)
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A Lteif
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F X Pi-Sunyer
(FX)
S Frances
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C Maggio
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E Ellis
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X Gong
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M A Banerji
(MA)
P August
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D Lorber
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N M Brown
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D H Josephson
(DH)
L L Thomas
(LL)
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A Waltje
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L Goodhall
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N Kessler
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K Whitley
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(ER)
A Bantle
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Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: JBG reports grants from NIDDK during the conduct of the study; and grants and personal fees from Boehringer Ingelheim/Lilly, personal fees from NovoNordisk, grants from Roche, personal fees from Hawthorne Effect/Omada, grants and personal fees from Sanofi/Lexicon, personal fees from Pfizer, grants from Glaxo SmithKline, personal fees from Bayer, grants from Merck, and grants and personal fees from AstraZeneca outside the submitted work. HA reports other from Novo Nordisk during the conduct of the study; and other from Novo Nordisk outside the submitted work. CD reports grants and personal fees from Novo Nordisk, personal fees from Astra Zeneca, grants from Sanofi, grants from the Department of Defense, and consultation for Bayer outside the submitted work. AJA reports personal fees from Novo Nordisk and personal fees from Lilly during the conduct of the study; and personal fees from Medtronic outside the submitted work. DJW reports other from Novo Nordisk outside the submitted work. VRA reports grants and other from Applied Therapeutics, grants and other from Fractyl, grants and other from Novo Nordisk, other from Pfizer, grants and other from Sanofi, other from Eli Lilly, and other from Janssen (Spouse) outside the submitted work. BIG, NMB, JHL, TH, HK-S and CES have nothing to disclose.
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