Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
May 2023
Historique:
received: 09 06 2022
accepted: 05 04 2023
revised: 06 03 2023
pubmed: 25 4 2023
medline: 25 4 2023
entrez: 24 04 2023
Statut: ppublish

Résumé

Studies applying Free Water Imaging have consistently reported significant global increases in extracellular free water (FW) in populations of individuals with early psychosis. However, these published studies focused on homogenous clinical participant groups (e.g., only first episode or chronic), thereby limiting our understanding of the time course of free water elevations across illness stages. Moreover, the relationship between FW and duration of illness has yet to be directly tested. Leveraging our multi-site diffusion magnetic resonance imaging(dMRI) harmonization approach, we analyzed dMRI scans collected by 12 international sites from 441 healthy controls and 434 individuals diagnosed with schizophrenia-spectrum disorders at different illness stages and ages (15-58 years). We characterized the pattern of age-related FW changes by assessing whole brain white matter in individuals with schizophrenia and healthy controls. In individuals with schizophrenia, average whole brain FW was higher than in controls across all ages, with the greatest FW values observed from 15 to 23 years (effect size range = [0.70-0.87]). Following this peak, FW exhibited a monotonic decrease until reaching a minima at the age of 39 years. After 39 years, an attenuated monotonic increase in FW was observed, but with markedly smaller effect sizes when compared to younger patients (effect size range = [0.32-0.43]). Importantly, FW was found to be negatively associated with duration of illness in schizophrenia (p = 0.006), independent of the effects of other clinical and demographic data. In summary, our study finds in a large, age-diverse sample that participants with schizophrenia with a shorter duration of illness showed higher FW values compared to participants with more prolonged illness. Our findings provide further evidence that elevations in the FW are present in individuals with schizophrenia, with the greatest differences in the FW being observed in those at the early stages of the disorder, which might suggest acute extracellular processes.

Identifiants

pubmed: 37095352
doi: 10.1038/s41380-023-02068-1
pii: 10.1038/s41380-023-02068-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2030-2038

Subventions

Organisme : Medical Research Council
ID : G0500092
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K01 MH115247
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH130781
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Suheyla Cetin-Karayumak (S)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. skarayumak@bwh.harvard.edu.

Amanda E Lyall (AE)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Maria A Di Biase (MA)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.

Johanna Seitz-Holland (J)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Fan Zhang (F)

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Sinead Kelly (S)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.

Doron Elad (D)

Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Godfrey Pearlson (G)

Department of Psychiatry, Yale University, New Haven, CT, USA.

Carol A Tamminga (CA)

Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.

John A Sweeney (JA)

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.

Brett A Clementz (BA)

Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA, USA.

David Schretlen (D)

Department of Psychiatry and Behavioral Sciences, Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Katharina Stegmayer (K)

University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Sebastian Walther (S)

University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Jungsun Lee (J)

Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Tim Crow (T)

Department of Psychiatry, SANE POWIC, Warneford Hospital, University of Oxford, Oxford, UK.

Anthony James (A)

Department of Psychiatry, SANE POWIC, Warneford Hospital, University of Oxford, Oxford, UK.

Aristotle Voineskos (A)

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Robert W Buchanan (RW)

Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Philip R Szeszko (PR)

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mental Illness Research, Education, and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.

Anil K Malhotra (AK)

The Feinstein Institutes for Medical Research and Zucker Hillside Hospital, Glen Oaks, NY, USA.

Matcheri Keshavan (M)

Department of Psychiatry, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.

Martha E Shenton (ME)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Yogesh Rathi (Y)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Ofer Pasternak (O)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Marek Kubicki (M)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Classifications MeSH