Coordinated prospective follow-up of Lynch syndrome is able to detect the majority of incident cancers.
Cancer genetics
Cancer prevention
Lynch syndrome
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
29
11
2022
revised:
28
03
2023
accepted:
28
03
2023
pubmed:
26
4
2023
medline:
26
4
2023
entrez:
25
4
2023
Statut:
ppublish
Résumé
Lynch syndrome is one of the most common genetic predispositions to many cancers, most of which do not have a consensus recommendation for screening. We studied in our region the value of a systematized and coordinated follow-up program for patients with Lynch syndrome on all organs at risk. A multicenter prospective cohort evaluation was performed, from January 2016 to June 2021. One hundred and seventy-eight patients were prospectively included (104 women (58%), median age 44 years, range 35-56 years) with a median follow-up of 4 years (range 2.5-5 years), corresponding to a total of 652 patient-years. The overall cancer incidence rate was 13.80 per 1000 patient-years. Seven of nine cancers (78%) were detected during the follow-up program, with all cancers identified at an early stage. The detection rate of adenomas during colonoscopies was 24%. These preliminary data suggest that coordinated prospective follow-up of Lynch syndrome is capable of detecting the majority of incident cancers, particularly for locations not covered by an international follow-up recommendation. However, these results need to be confirmed by larger-scale studies.
Sections du résumé
BACKGROUND
BACKGROUND
Lynch syndrome is one of the most common genetic predispositions to many cancers, most of which do not have a consensus recommendation for screening.
AIMS
OBJECTIVE
We studied in our region the value of a systematized and coordinated follow-up program for patients with Lynch syndrome on all organs at risk.
METHODS
METHODS
A multicenter prospective cohort evaluation was performed, from January 2016 to June 2021.
RESULTS
RESULTS
One hundred and seventy-eight patients were prospectively included (104 women (58%), median age 44 years, range 35-56 years) with a median follow-up of 4 years (range 2.5-5 years), corresponding to a total of 652 patient-years. The overall cancer incidence rate was 13.80 per 1000 patient-years. Seven of nine cancers (78%) were detected during the follow-up program, with all cancers identified at an early stage. The detection rate of adenomas during colonoscopies was 24%.
CONCLUSION
CONCLUSIONS
These preliminary data suggest that coordinated prospective follow-up of Lynch syndrome is capable of detecting the majority of incident cancers, particularly for locations not covered by an international follow-up recommendation. However, these results need to be confirmed by larger-scale studies.
Identifiants
pubmed: 37098454
pii: S1590-8658(23)00530-3
doi: 10.1016/j.dld.2023.03.016
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1735-1741Informations de copyright
Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.