Dietary Supplementation with the Probiotic SF68 Reinforces Intestinal Epithelial Barrier in Obese Mice by Improving Butyrate Bioavailability.

Male Animals Mice Butyrates Mice, Obese Biological Availability Mice, Inbred C57BL Obesity / metabolism Probiotics / pharmacology Inflammation Diet, High-Fat / adverse effects Tight Junction Proteins / metabolism
SF68 butyrate intestinal epithelial barrier obesity tight junctions

Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
07 2023
Historique:
revised: 07 02 2023
received: 29 11 2022
medline: 5 7 2023
pubmed: 26 4 2023
entrez: 26 4 2023
Statut: ppublish

Résumé

Modifications in intestinal microbiota and its metabolites, the short-chain fatty acids (SCFA) are main factors altering intestinal epithelial barrier integrity and eliciting the onset of a meta-inflammation observed in obesity. The present study is aimed at evaluating the efficacy of Enterococcus faecium (SF68) administration in counteracting the impairment of gut barrier and enteric inflammation in a model of diet-induced obesity, characterizing the molecular mechanisms underlying such beneficial effects. Male C57BL/6J mice, fed with standard diet (SD) or high-fat diet (HFD), are treated with SF68 (10 Supplementation with SF68 reduces intestinal inflammation and reinforces the enteric epithelial barrier in obese mice, improving the transport and utilization of butyrate.

Identifiants

DOI: 10.1002/mnfr.202200442 PMID: 37099449
pubmed: 37099449
doi: 10.1002/mnfr.202200442
doi:

Substances chimiques

Butyrates 0
Tight Junction Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2200442

Informations de copyright

© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.

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Auteurs

Laura Benvenuti (L)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
ORCID: 0000-0001-6576-5053

Vanessa D'Antongiovanni (V)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Carolina Pellegrini (C)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Matteo Fornai (M)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Nunzia Bernardini (N)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

Chiara Ippolito (C)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Cristina Segnani (C)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Clelia Di Salvo (C)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Rocchina Colucci (R)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Alma Martelli (A)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Lorenzo Flori (L)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Vincenzo Calderone (V)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Gianfranca Carta (G)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Emilia Ghelardi (E)

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Marco Calvigioni (M)

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Adelaide Panattoni (A)

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Raffaella Coppolecchia (R)

Cerbios Pharma-SA, Lugano, Switzerland.

Achille Arini (A)

Cerbios Pharma-SA, Lugano, Switzerland.

Luca Antonioli (L)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Butyrates › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris obèse › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Dietary Supplementation with the Probiotic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la jonction serrée › Dietary Supplementation with the Probiotic...