Association of ABO and RhD blood groups with the risk of HIV infection.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
10
2022
accepted:
12
04
2023
medline:
28
4
2023
pubmed:
26
4
2023
entrez:
26
4
2023
Statut:
epublish
Résumé
Naturally occurring antibodies against ABO antigens present in human sera have been shown to neutralize ABO-expressing HIV in vitro. We investigated associations between ABO and RhD blood groups and HIV infection among blood donors from all blood collection centers in eight of South Africa's nine provinces. Whole blood donations collected from first time donors between January 2012 and September 2016 were tested for HIV RNA by nucleic acid testing and HIV antibody using third generation serology assays. ABO and RhD blood types were determined using automated technology. Odds ratios for the association between HIV positivity and ABO and RhD phenotypes were calculated using multivariable logistic regression analysis. We analyzed 515,945 first time blood donors and the overall HIV prevalence was 1.12% (n = 5790). After multivariable adjustment, HIV infection was weakly associated with RhD positive phenotype (OR = 1.15, 95% CI 1.00-1.33) but not with ABO blood group. The observed association with RhD positive phenotype was marginal and likely due to residual confounding by racial group but could serve to generate hypotheses for further studies.
Identifiants
pubmed: 37099490
doi: 10.1371/journal.pone.0284975
pii: PONE-D-22-29670
pmc: PMC10132593
doi:
Substances chimiques
ABO Blood-Group System
0
Antigens
0
Rho(D) antigen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0284975Subventions
Organisme : FIC NIH HHS
ID : D43 TW010345
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100009I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002I
Pays : United States
Informations de copyright
Copyright: © 2023 Jacobs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Equity Health. 2019 Oct 30;18(1):167
pubmed: 31666077
Clin Microbiol Rev. 2015 Jul;28(3):801-70
pubmed: 26085552
Emerg Infect Dis. 2017 Sep;23(9):1560-1563
pubmed: 28820374
Emerg Infect Dis. 1998 Jul-Sep;4(3):410-1
pubmed: 9716958
MMWR Morb Mortal Wkly Rep. 1982 Dec 10;31(48):652-4
pubmed: 6819440
Epidemics. 2021 Jun;35:100446
pubmed: 33706041
Blood. 1987 Nov;70(5):1604-10
pubmed: 3663947
Front Microbiol. 2022 Jan 05;12:799519
pubmed: 35069504
Transfusion. 2013 Feb;53(2):438-54
pubmed: 22690676
Hum Mol Genet. 2010 Feb 1;19(3):411-9
pubmed: 19892779
Hematol Rep. 2014 Dec 04;6(4):5602
pubmed: 25568761
Vox Sang. 2021 Jan;116(1):15-17
pubmed: 32965025
Transfus Apher Sci. 2018 Feb;57(1):58-62
pubmed: 29269123
Nat Commun. 2017 Dec 12;8(1):2062
pubmed: 29233967
Eur J Microbiol Immunol (Bp). 2015 Sep 18;5(3):205-9
pubmed: 26495131
Blood. 2005 Jun 15;105(12):4693-9
pubmed: 15728127
Blood. 2010 Jun 10;115(23):4635-43
pubmed: 20308598
J Clin Diagn Res. 2013 Sep;7(9):1930-1
pubmed: 24179900