Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice.
Journal
The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
Titre abrégé: J Antimicrob Chemother
Pays: England
ID NLM: 7513617
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
17
11
2022
accepted:
17
03
2023
medline:
2
6
2023
pubmed:
26
4
2023
entrez:
26
4
2023
Statut:
ppublish
Résumé
To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018-2021. We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens. We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n = 282, 13.1%), DTG/3TC/abacavir (ABC) (n = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n = 126, 5.8%). At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47; 95% CI: 0.30-0.74) compared with dolutegravir/lamivudine.For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event. In this large multicentre cohort, effectiveness and tolerability of dolutegravir/lamivudine were high among treatment-naive and treatment-experienced subjects.
Identifiants
pubmed: 37099559
pii: 7143330
doi: 10.1093/jac/dkad102
pmc: PMC10232237
doi:
Substances chimiques
dolutegravir
DKO1W9H7M1
Anti-HIV Agents
0
Lamivudine
2T8Q726O95
Oxazines
0
Heterocyclic Compounds, 3-Ring
0
Pyridones
0
Emtricitabine
G70B4ETF4S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1423-1432Investigateurs
Santiago Moreno
(S)
Inma Jarrín
(I)
David Dalmau
(D)
M Luisa Navarro
(ML)
M Isabel González
(MI)
Federico Garcia
(F)
Eva Poveda
(E)
Jose Antonio Iribarren
(JA)
Félix Gutiérrez
(F)
Rafael Rubio
(R)
Francesc Vidal
(F)
Juan Berenguer
(J)
Juan González
(J)
M Ángeles Muñoz-Fernández
(MÁ)
Inmaculada Jarrín
(I)
Cristina Moreno
(C)
Marta Rava
(M)
Rebeca Izquierdo
(R)
Jorge Del Romero Raposo
(J)
Cristina Marco
(C)
Julián Puente
(J)
M Ángeles Muñoz-Fernández
(MÁ)
Elba Mauleón
(E)
Roxana Juárez
(R)
Joaquín Portilla
(J)
Irene Portilla
(I)
Esperanza Merino
(E)
Gema García
(G)
Iván Agea
(I)
José Sánchez-Payá
(J)
Juan Carlos Rodríguez
(JC)
Livia Giner
(L)
Sergio Reus
(S)
Vicente Boix
(V)
Diego Torrus
(D)
Verónica Pérez
(V)
Julia Portilla
(J)
María Remedios Alemán
(MR)
Jehovana Hernández
(J)
Ana López Lirola
(AL)
Dácil García
(D)
Felicitas Díaz-Flores
(F)
M Mar Alonso
(MM)
Ricardo Pelazas
(R)
Víctor Asensi
(V)
M Eugenia Rivas
(ME)
Tomás Suarez-Zarracina
(T)
Eulalia Valle-Garay
(E)
Javier Díaz
(J)
Federico Pulido
(F)
Rafael Rubio
(R)
Otilia Bisbal
(O)
M Asunción Hernando
(MA)
David Rial
(D)
María de Lagarde
(M)
Octavio Arce
(O)
Adriana Pinto
(A)
Laura Bermejo
(L)
Mireia Santacreu
(M)
Roser Navarro
(R)
Candela Gonzalez
(C)
Jose Antonio Iribarren
(JA)
M José Aramburu
(MJ)
Xabier Camino
(X)
Miguel Ángel von Wichmann
(MÁ)
Miguel Ángel Goenaga
(MÁ)
M Jesús Bustinduy
(MJ)
Harkaitz Azkune
(H)
Maialen Ibarguren
(M)
Xabier Kortajarena
(X)
Ignacio Álvarez-Rodriguez
(I)
Leire Gil
(L)
Lourdes Martínez
(L)
Félix Gutiérrez
(F)
Mar Masiá
(M)
Catalina Robledano
(C)
Sergio Padilla
(S)
Javier Garcia Abellán
(JG)
Paula Mascarell
(P)
Araceli Adsuar
(A)
Rafael Pascual
(R)
Mar Carvajal
(M)
Marta Fernández
(M)
José Alberto García
(JA)
Ángela Botella
(Á)
Alba de la Rica
(A)
Carolina Ding
(C)
Lidia García-Sánchez
(L)
Nuria Ena
(N)
Xavier Barber
(X)
Vanessa Agullo
(V)
Reyes Pascual
(R)
Guillermo Telenti
(G)
Lucia Guillén
(L)
Leandro López
(L)
Jennifer Vallejo
(J)
Nieves Gonzalo-Jimenez
(N)
Montserrat Ruiz
(M)
Antonio Galiana
(A)
Roberto Muga
(R)
Arantza Sanvisens
(A)
Daniel Fuster
(D)
Juan Carlos López Bernaldo de Quirós
(JCLB)
Isabel Gutierrez
(I)
Margarita Ramírez
(M)
Belén Padilla
(B)
Paloma Gijón
(P)
Teresa Aldamiz-Echevarría
(T)
Francisco Tejerina
(F)
Cristina Diez
(C)
Leire Pérez
(L)
Chiara Fanciulli
(C)
Saray Corral
(S)
Joaquín Peraire
(J)
Anna Martí
(A)
Consuelo Viladés
(C)
Montserrat Vargas
(M)
Montserrat Olona
(M)
Anna Rull
(A)
Verónica Alba
(V)
Elena Yeregui
(E)
Jenifer Masip
(J)
Graciano García-Pardo
(G)
Frederic Gómez Bertomeu
(FG)
Sonia Espineira
(S)
Marta Montero
(M)
Marino Blanes
(M)
María Tasias
(M)
Eva Calabuig
(E)
Miguel Salavert
(M)
Juan Fernández
(J)
Inmaculada Segarra
(I)
Juan González-García
(J)
Ana Delgado-Hierro
(A)
José Ramón Arribas
(JR)
Victor Arribas
(V)
Jose Ignacio Bernardino
(JI)
Carmen Busca
(C)
Joanna Cano
(J)
Julen Cadiñanos
(J)
Juan Miguel Castro
(JM)
Luis Escosa
(L)
Iker Falces
(I)
Pedro Herranz
(P)
Victor Hontañón
(V)
Milagros García
(M)
Alicia González-Baeza
(A)
M Luz Martín-Carbonero
(ML)
Mario Mayoral
(M)
Mª Jose Mellado
(MJ)
Rafael Micán
(R)
Rosa de Miguel
(R)
Rocío Montejano
(R)
M Luisa Montes
(ML)
Victoria Moreno
(V)
Luis Ramos Berta Rodés
(LRB)
Talía Sainz
(T)
Elena Sendagorta
(E)
Eulalia Valencia
(E)
Jose Ramón Blanco
(JR)
Laura Pérez-Martínez
(L)
José Antonio Oteo
(JA)
Valvanera Ibarra
(V)
Luis Metola
(L)
Mercedes Sanz
(M)
Rosa Martínez
(R)
Gloria Sampériz
(G)
David Dalmau
(D)
Marina Martinez
(M)
Angels Jaén
(A)
Mireia Cairó
(M)
Javier Martinez-Lacasa
(J)
Roser Font
(R)
Laura Gisbert
(L)
María Rivero
(M)
Beatriz Piérola
(B)
Maider Goikoetxea
(M)
María Gracia
(M)
Carlos Ibero
(C)
Estela Moreno
(E)
Jesús Repáraz
(J)
Gemma Navarro
(G)
Manel Cervantes Garcia
(MC)
Sonia Calzado Isbert
(SC)
Marta Navarro Vilasaro
(MN)
Belen Lopez Garcia
(BL)
Ignacio de Los Santos
(I)
Alejandro de Los Santos
(A)
Jesús Sanz
(J)
Lucio García-Fraile
(L)
Enrique Martín
(E)
Ildefonso Sánchez-Cerrillo
(I)
Marta Calvet
(M)
Ana Barrios
(A)
Azucena Bautista
(A)
Carmen Sáez
(C)
Marianela Ciudad
(M)
Ángela Gutiérrez
(Á)
Santiago Moreno
(S)
Santos Del Campo
(S)
José Luis Casado
(JL)
Fernando Dronda
(F)
Ana Moreno
(A)
M Jesús Pérez
(MJ)
Sergio Serrano
(S)
M Jesús Vivancos
(MJ)
Javier Martínez-Sanz
(J)
Alejandro Vallejo
(A)
Matilde Sanchez
(M)
Jose Antonio Pérez-Molina
(JA)
José Manuel Hermida
(JM)
Enrique Bernal
(E)
Antonia Alcaraz
(A)
Joaquín Bravo
(J)
Ángeles Muñoz
(Á)
Cristina Tomás
(C)
Mónica Martínez
(M)
M Carmen Villalba
(MC)
Federico García
(F)
Clara Martínez
(C)
José Hernández
(J)
Leopoldo Muñoz Medina
(LM)
Marta Álvarez
(M)
Natalia Chueca
(N)
David Vinuesa
(D)
Adolfo de Salazar
(A)
Ana Fuentes
(A)
Emilio Guirao
(E)
Laura Viñuela
(L)
Andrés Ruiz-Sancho
(A)
Francisco Anguita
(F)
Jorge Del Romero
(J)
Montserrat Raposo
(M)
Carmen Rodríguez
(C)
Teresa Puerta
(T)
Juan Carlos Carrió
(JC)
Mar Vera
(M)
Juan Ballesteros
(J)
Oskar Ayerdi
(O)
Begoña Baza
(B)
Eva Orviz
(E)
Antonio Antela
(A)
Elena Losada
(E)
Melchor Riera
(M)
María Peñaranda
(M)
M Angels Ribas
(MA)
Antoni A Campins
(AA)
Mercedes Garcia-Gazalla
(M)
Francisco J Fanjul
(FJ)
Javier Murillas
(J)
Francisco Homar
(F)
Helem H Vilchez
(HH)
Luisa Martin
(L)
Antoni Payeras
(A)
Jesús Santos
(J)
María López
(M)
Cristina Gómez
(C)
Isabel Viciana
(I)
Rosario Palacios
(R)
Luis Fernando López-Cortés
(LF)
Nuria Espinosa
(N)
Cristina Roca
(C)
Silvia Llaves
(S)
Juan Manuel Tiraboschi
(JM)
Arkaitz Imaz
(A)
Ana Karina Silva
(AK)
María Saumoy
(M)
Sofía Catalina Scévola
(SC)
Adrián Curran
(A)
Vicenç Falcó
(V)
Jordi Navarro
(J)
Joaquin Burgos
(J)
Paula Suanzes
(P)
Jorge García
(J)
Vicente Descalzo
(V)
Patricia Álvarez
(P)
Bibiana Planas
(B)
Marta Sanchiz
(M)
Lucía Rodríguez
(L)
Julián Olalla
(J)
M José Sánchez
(MJ)
Javier Pérez
(J)
Alfonso Del Arco
(A)
Javier de la Torre
(J)
José Luis Prada
(JL)
Onofre Juan Martínez
(OJ)
Lorena Martinez
(L)
Francisco Jesús Vera
(FJ)
Josefina García
(J)
Begoña Alcaraz
(B)
Antonio Jesús Sánchez Guirao
(AJS)
Álvaro Mena
(Á)
Ángeles Castro
(Á)
Berta Pernas
(B)
Pilar Vázquez
(P)
Soledad López
(S)
Sofía Ibarra
(S)
Guillermo García
(G)
Josu Mirena
(J)
Oscar Luis Ferrero
(OL)
Josefina López
(J)
M Mar Cámara
(MM)
Mireia de la Peña
(M)
Miriam Lopez
(M)
Iñigo Lopez
(I)
Itxaso Lombide
(I)
Victor Polo
(V)
Joana de Miguel
(J)
Carlos Galera
(C)
Marian Fernández
(M)
Helena Albendin
(H)
Antonia Castillo
(A)
Asunción Iborra
(A)
Antonio Moreno
(A)
M Angustias Merlos
(MA)
Asunción Vidal
(A)
Concha Amador
(C)
Francisco Pasquau
(F)
Concepción Gil
(C)
Jose Tomás Algado
(JT)
Inés Suarez-García
(I)
Eduardo Malmierca
(E)
Patricia González-Ruano
(P)
M Pilar Ruiz
(MP)
José Francisco Pascual
(JF)
Luz Balsalobre
(L)
Ángela Somodevilla
(Á)
M Villa López
(MV)
Mohamed Omar
(M)
Carmen Herrero
(C)
M Amparo Gómez
(MA)
Miguel Alberto de Zarraga
(MA)
Desiré Pérez
(D)
Vicente Estrada
(V)
Nieves Sanz
(N)
Noemí Cabello
(N)
Jorge Vergas
(J)
M Jose Núñez
(MJ)
Iñigo Sagastagoitia
(I)
Reynaldo Homen
(R)
Ana Muñoz
(A)
Miguel Górgolas
(M)
Alfonso Cabello
(A)
Beatriz Álvarez
(B)
Laura Prieto
(L)
Irene Carrillo
(I)
Aws Al-Hayani
(A)
José Sanz
(J)
Alberto Arranz
(A)
Cristina Hernández
(C)
María Novella
(M)
M José Galindo
(MJ)
Ana Ferrer
(A)
Antonio Rivero Román
(AR)
Inma Ruíz
(I)
Antonio Rivero Juárez
(AR)
Pedro López
(P)
Isabel Machuca
(I)
Mario Frías
(M)
Ángela Camacho
(Á)
Ignacio Pérez
(I)
Diana Corona
(D)
Ignacio Pérez
(I)
Diana Corona
(D)
Miguel Cervero
(M)
Rafael Torres
(R)
Juan Macías Sánchez
(JM)
Pilar Rincón
(P)
Luis Miguel Real
(LM)
Anais Corma
(A)
Marta Fernández
(M)
Alejandro González-Serna
(A)
Eva Poveda
(E)
Alexandre Pérez
(A)
Luis Morano
(L)
Celia Miralles
(C)
Antonio Ocampo
(A)
Guillermo Pousada
(G)
Lucía Patiño
(L)
Carlos Dueñas
(C)
Sara Gutiérrez
(S)
Elena Tapia
(E)
Cristina Novoa
(C)
Xjoylin Egües
(X)
Pablo Telleria
(P)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.
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