Loss of hyaluronan synthases impacts bone morphology, quality, and mechanical properties.

Female Mice Animals Hyaluronan Synthases / genetics Glucuronosyltransferase / genetics Hyaluronic Acid
Bone quality Hyaluronan Hyaluronan synthase

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
07 2023
Historique:
received: 08 12 2022
revised: 18 04 2023
accepted: 20 04 2023
medline: 22 5 2023
pubmed: 27 4 2023
entrez: 26 4 2023
Statut: ppublish

Résumé

Hyaluronan, a glycosaminoglycan synthesized by three isoenzymes (Has1, Has2, Has3), is known to play a role in regulating bone turnover, remodeling, and mineralization, which in turn can affect bone quality and strength. The goal of this study is to characterize how the loss of Has1 or Has3 affects the morphology, matrix properties, and overall strength of murine bone. Femora were isolated from Has1

Identifiants

DOI: 10.1016/j.bone.2023.116779 PMID: 37100359
pubmed: 37100359
pii: S8756-3282(23)00112-6
doi: 10.1016/j.bone.2023.116779
pii:
doi:

Substances chimiques

Hyaluronan Synthases EC 2.4.1.212
Glucuronosyltransferase EC 2.4.1.17
Hyaluronic Acid 9004-61-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116779

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Meghana Pendyala (M)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America.

Samuel J Stephen (SJ)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America.

Deepak Vashishth (D)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America.

Elizabeth A Blaber (EA)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Blue Marble Space Institute of Science at NASA Ames Research Center, PO Box 1, Moffett Field, CA 94035, United States of America.

Deva D Chan (DD)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8(th) St. Troy, NY 12180, United States of America; Weldon School of Biomedical Engineering, 206 S. Martin Jischke Drive, Purdue University, West Lafayette, IN 47907, United States of America. Electronic address: chand@purdue.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of hyaluronan synthases impacts bone...
questionsmedicales.fr › Eucaryotes › Animaux › Loss of hyaluronan synthases impacts bone...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Hyaluronan synthases › Loss of hyaluronan synthases impacts bone...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Loss of hyaluronan synthases impacts bone...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Acide hyaluronique › Loss of hyaluronan synthases impacts bone...