Characteristics of Electrical Synapses, C-terminals and Small-conductance Ca
C-terminals
Cx36(BAC)::eGFP mice
connexin36
cremaster motoneurons
cremaster muscle
neuronal gap junctions
serotonin
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 06 2023
15 06 2023
Historique:
received:
15
11
2022
revised:
17
03
2023
accepted:
18
04
2023
medline:
12
6
2023
pubmed:
27
4
2023
entrez:
26
4
2023
Statut:
ppublish
Résumé
Sexually dimorphic motoneurons (MNs) located in lower lumbar spinal cord are involved in mating and reproductive behaviours and are known to be coupled by electrical synapses. The cremaster motor nucleus in upper lumbar spinal cord has also been suggested to support physiological processes associated with sexual behaviours in addition to its thermoregulatory and protective role in maintaining testes integrity. Using immunofluorescence approaches, we investigated whether cremaster MNs also exhibit features reflecting their potential for electrical synaptic communication and examined some of their other synaptic characteristics. Both mice and rats displayed punctate immunolabelling of Cx36 associated with cremaster MNs, indicative of gap junction formation. Transgenic mice with enhanced green fluorescent protein (eGFP) reporter for connexin36 expression showed that subpopulations of cremaster MNs in both male and female mice express eGFP, with greater proportions of those in male mice. The eGFP
Identifiants
pubmed: 37100373
pii: S0306-4522(23)00179-3
doi: 10.1016/j.neuroscience.2023.04.013
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-76Informations de copyright
Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.