Apoptotic cell death in disease-Current understanding of the NCCD 2023.


Journal

Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445

Informations de publication

Date de publication:
05 2023
Historique:
received: 30 01 2023
accepted: 17 03 2023
revised: 10 03 2023
medline: 4 5 2023
pubmed: 27 4 2023
entrez: 26 4 2023
Statut: ppublish

Résumé

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Identifiants

pubmed: 37100955
doi: 10.1038/s41418-023-01153-w
pii: 10.1038/s41418-023-01153-w
pmc: PMC10130819
doi:

Substances chimiques

Caspases EC 3.4.22.-

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1097-1154

Subventions

Organisme : NINDS NIH HHS
ID : R21 NS127076
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG063012
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178394
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238229
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA271346
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237264
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA267696
Pays : United States
Organisme : NIA NIH HHS
ID : R35 AG071734
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.

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Auteurs

Ilio Vitale (I)

IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy. iliovit@gmail.com.
Candiolo Cancer Institute, FPO -IRCCS, Candiolo, Italy. iliovit@gmail.com.

Federico Pietrocola (F)

Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.

Emma Guilbaud (E)

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Stuart A Aaronson (SA)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

John M Abrams (JM)

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Dieter Adam (D)

Institut für Immunologie, Kiel University, Kiel, Germany.

Massimiliano Agostini (M)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Patrizia Agostinis (P)

Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
VIB Center for Cancer Biology, Leuven, Belgium.

Emad S Alnemri (ES)

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Lucia Altucci (L)

Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
BIOGEM, Avellino, Italy.

Ivano Amelio (I)

Division of Systems Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.

David W Andrews (DW)

Sunnybrook Research Institute, Toronto, ON, Canada.
Departments of Biochemistry and Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Rami I Aqeilan (RI)

Hebrew University of Jerusalem, Lautenberg Center for Immunology & Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Jerusalem, Israel.

Eli Arama (E)

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Eric H Baehrecke (EH)

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Siddharth Balachandran (S)

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

Daniele Bano (D)

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.

Nickolai A Barlev (NA)

Department of Biomedicine, Nazarbayev University School of Medicine, Astana, Kazakhstan.

Jiri Bartek (J)

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Danish Cancer Society Research Center, Copenhagen, Denmark.

Nicolas G Bazan (NG)

Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.

Christoph Becker (C)

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Francesca Bernassola (F)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Mathieu J M Bertrand (MJM)

VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Marco E Bianchi (ME)

Università Vita-Salute San Raffaele, School of Medicine, Milan, Italy and Ospedale San Raffaele IRCSS, Milan, Italy.

Mikhail V Blagosklonny (MV)

Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

J Magarian Blander (JM)

Department of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
Sandra and Edward Meyer Cancer Center, New York, NY, USA.

Giovanni Blandino (G)

IRCSS Regina Elena National Cancer Institute, Rome, Italy.

Klas Blomgren (K)

Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.

Christoph Borner (C)

Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert Ludwigs University of Freiburg, Freiburg, Germany.

Carl D Bortner (CD)

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA.

Pierluigi Bove (P)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Patricia Boya (P)

Centro de Investigaciones Biologicas Margarita Salas, CSIC, Madrid, Spain.

Catherine Brenner (C)

Université Paris-Saclay, CNRS, Institut Gustave Roussy, Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques, Villejuif, France.

Petr Broz (P)

Department of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland.

Thomas Brunner (T)

Department of Biology, University of Konstanz, Konstanz, Germany.

Rune Busk Damgaard (RB)

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

George A Calin (GA)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Michelangelo Campanella (M)

Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
UCL Consortium for Mitochondrial Research, London, UK.
Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Eleonora Candi (E)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Michele Carbone (M)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA.

Didac Carmona-Gutierrez (D)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

Francesco Cecconi (F)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.

Francis K-M Chan (FK)

Department of Immunology, Duke University School of Medicine, Durham, NC, USA.

Guo-Qiang Chen (GQ)

State Key Lab of Oncogene and its related gene, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Quan Chen (Q)

College of Life Sciences, Nankai University, Tianjin, China.

Youhai H Chen (YH)

Shenzhen Institute of Advanced Technology (SIAT), Shenzhen, Guangdong, China.

Emily H Cheng (EH)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Jerry E Chipuk (JE)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

John A Cidlowski (JA)

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA.

Aaron Ciechanover (A)

The Technion-Integrated Cancer Center, The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Gennaro Ciliberto (G)

IRCSS Regina Elena National Cancer Institute, Rome, Italy.

Marcus Conrad (M)

Helmholtz Munich, Institute of Metabolism and Cell Death, Neuherberg, Germany.

Juan R Cubillos-Ruiz (JR)

Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.

Peter E Czabotar (PE)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Vincenzo D'Angiolella (V)

Department of Oncology, University of Oxford, Oxford, UK.

Mads Daugaard (M)

Department of Urologic Sciences, Vancouver Prostate Centre, Vancouver, BC, Canada.

Ted M Dawson (TM)

Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Valina L Dawson (VL)

Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Ruggero De Maria (R)

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.

Bart De Strooper (B)

VIB Centre for Brain & Disease Research, Leuven, Belgium.
Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
The Francis Crick Institute, London, UK.
UK Dementia Research Institute at UCL, University College London, London, UK.

Klaus-Michael Debatin (KM)

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.

Ralph J Deberardinis (RJ)

Howard Hughes Medical Institute and Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Alexei Degterev (A)

Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.

Giannino Del Sal (G)

Department of Life Sciences, University of Trieste, Trieste, Italy.
International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park-Padriciano, Trieste, Italy.
IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy.

Mohanish Deshmukh (M)

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.

Francesco Di Virgilio (F)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Marc Diederich (M)

College of Pharmacy, Seoul National University, Seoul, South Korea.

Scott J Dixon (SJ)

Department of Biology, Stanford University, Stanford, CA, USA.

Brian D Dynlacht (BD)

Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA.

Wafik S El-Deiry (WS)

Division of Hematology/Oncology, Brown University and the Lifespan Cancer Institute, Providence, RI, USA.
Legorreta Cancer Center at Brown University, The Warren Alpert Medical School, Brown University, Providence, RI, USA.
Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School, Brown University, Providence, RI, USA.

John W Elrod (JW)

Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Kurt Engeland (K)

Molecular Oncology, University of Leipzig, Leipzig, Germany.

Gian Maria Fimia (GM)

Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Claudia Galassi (C)

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Carlo Ganini (C)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Biochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy.

Ana J Garcia-Saez (AJ)

CECAD, Institute of Genetics, University of Cologne, Cologne, Germany.

Abhishek D Garg (AD)

Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Carmen Garrido (C)

INSERM, UMR, 1231, Dijon, France.
Faculty of Medicine, Université de Bourgogne Franche-Comté, Dijon, France.
Anti-cancer Center Georges-François Leclerc, Dijon, France.

Evripidis Gavathiotis (E)

Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.
Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.
Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY, USA.

Motti Gerlic (M)

Department of Clinical Microbiology and Immunology, Sackler school of Medicine, Tel Aviv university, Tel Aviv, Israel.

Sourav Ghosh (S)

Department of Neurology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

Douglas R Green (DR)

Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.

Lloyd A Greene (LA)

Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.

Hinrich Gronemeyer (H)

Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.
Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.
Université de Strasbourg, Illkirch, France.

Georg Häcker (G)

Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

György Hajnóczky (G)

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

J Marie Hardwick (JM)

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Departments of Molecular Microbiology and Immunology, Pharmacology, Oncology and Neurology, Johns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, MD, USA.

Ygal Haupt (Y)

VITTAIL Ltd, Melbourne, VIC, Australia.
Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Sudan He (S)

Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.

David M Heery (DM)

School of Pharmacy, University of Nottingham, Nottingham, UK.

Michael O Hengartner (MO)

ETH Board, Zurich, Switzerland.

Claudio Hetz (C)

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Buck Institute for Research on Aging, Novato, CA, USA.

David A Hildeman (DA)

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Hidenori Ichijo (H)

Laboratory of Cell Signaling, The University of Tokyo, Tokyo, Japan.

Satoshi Inoue (S)

National Cancer Center Research Institute, Tokyo, Japan.

Marja Jäättelä (M)

Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Ana Janic (A)

Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.

Bertrand Joseph (B)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Philipp J Jost (PJ)

Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Thirumala-Devi Kanneganti (TD)

Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.

Michael Karin (M)

Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, San Diego, CA, USA.

Hamid Kashkar (H)

CECAD Research Center, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.

Thomas Kaufmann (T)

Institute of Pharmacology, University of Bern, Bern, Switzerland.

Gemma L Kelly (GL)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Oliver Kepp (O)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

Adi Kimchi (A)

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Richard N Kitsis (RN)

Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.
Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.
Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, New York, NY, USA.

Daniel J Klionsky (DJ)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Ruth Kluck (R)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Dmitri V Krysko (DV)

Cell Death Investigation and Therapy Lab, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

Dagmar Kulms (D)

Department of Dermatology, Experimental Dermatology, TU-Dresden, Dresden, Germany.
National Center for Tumor Diseases Dresden, TU-Dresden, Dresden, Germany.

Sharad Kumar (S)

Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.

Sergio Lavandero (S)

Universidad de Chile, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Inna N Lavrik (IN)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

John J Lemasters (JJ)

Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.

Gianmaria Liccardi (G)

Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.

Andreas Linkermann (A)

Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Biotechnology Center, Technische Universität Dresden, Dresden, Germany.

Stuart A Lipton (SA)

Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

Richard A Lockshin (RA)

Department of Biology, Queens College of the City University of New York, Flushing, NY, USA.
St. John's University, Jamaica, NY, USA.

Carlos López-Otín (C)

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

Tom Luedde (T)

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany.

Marion MacFarlane (M)

Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.

Frank Madeo (F)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
BioTechMed Graz, Graz, Austria.
Field of Excellence BioHealth - University of Graz, Graz, Austria.

Walter Malorni (W)

Center for Global Health, Università Cattolica del Sacro Cuore, Rome, Italy.

Gwenola Manic (G)

IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy.
Candiolo Cancer Institute, FPO -IRCCS, Candiolo, Italy.

Roberto Mantovani (R)

Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy.

Saverio Marchi (S)

Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.

Jean-Christophe Marine (JC)

VIB Center for Cancer Biology, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Seamus J Martin (SJ)

Department of Genetics, Trinity College, Dublin, 2, Ireland.

Jean-Claude Martinou (JC)

Department of Cell Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.

Pier G Mastroberardino (PG)

Department of Molecular Genetics, Rotterdam, the Netherlands.
IFOM-ETS The AIRC Institute for Molecular Oncology, Milan, Italy.
Department of Life, Health, and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Jan Paul Medema (JP)

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Oncode Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Patrick Mehlen (P)

Apoptosis, Cancer, and Development Laboratory, Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, Lyon, France.

Pascal Meier (P)

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Gerry Melino (G)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Sonia Melino (S)

Department of Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy.

Edward A Miao (EA)

Department of Immunology, Duke University School of Medicine, Durham, NC, USA.

Ute M Moll (UM)

Department of Pathology and Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.

Cristina Muñoz-Pinedo (C)

Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.

Daniel J Murphy (DJ)

School of Cancer Sciences, University of Glasgow, Glasgow, UK.
Cancer Research UK Beatson Institute, Glasgow, UK.

Maria Victoria Niklison-Chirou (MV)

Department of Pharmacy & Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath, UK.

Flavia Novelli (F)

Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA.

Gabriel Núñez (G)

Department of Pathology and Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA.

Andrew Oberst (A)

Department of Immunology, University of Washington, Seattle, WA, USA.

Dimitry Ofengeim (D)

Rare and Neuroscience Therapeutic Area, Sanofi, Cambridge, MA, USA.

Joseph T Opferman (JT)

Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Moshe Oren (M)

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel.

Michele Pagano (M)

Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine and Howard Hughes Medical Institute, New York, NY, USA.

Theocharis Panaretakis (T)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of GU Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Manolis Pasparakis (M)

CECAD, Institute of Genetics, University of Cologne, Cologne, Germany.

Josef M Penninger (JM)

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada.

Francesca Pentimalli (F)

Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy.

David M Pereira (DM)

REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

Shazib Pervaiz (S)

Department of Physiology, YLL School of Medicine, National University of Singapore, Singapore, Singapore.
NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore.
National University Cancer Institute, NUHS, Singapore, Singapore.
ISEP, NUS Graduate School, National University of Singapore, Singapore, Singapore.

Marcus E Peter (ME)

Department of Medicine, Division Hematology/Oncology, Northwestern University, Chicago, IL, USA.

Paolo Pinton (P)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Giovanni Porta (G)

Center of Genomic Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Jochen H M Prehn (JHM)

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin 2, Ireland.

Hamsa Puthalakath (H)

Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.

Gabriel A Rabinovich (GA)

Laboratorio de Glicomedicina. Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Krishnaraj Rajalingam (K)

Cell Biology Unit, University Medical Center Mainz, Mainz, Germany.

Kodi S Ravichandran (KS)

VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Center for Cell Clearance, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.

Markus Rehm (M)

Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.

Jean-Ehrland Ricci (JE)

Université Côte d'Azur, INSERM, C3M, Equipe labellisée Ligue Contre le Cancer, Nice, France.

Rosario Rizzuto (R)

Department of Biomedical Sciences, University of Padua, Padua, Italy.

Nirmal Robinson (N)

Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.

Cecilia M P Rodrigues (CMP)

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

Barak Rotblat (B)

Department of Life sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
The NIBN, Beer Sheva, Israel.

Carla V Rothlin (CV)

Department of Immunobiology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

David C Rubinsztein (DC)

Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK.
UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK.

Thomas Rudel (T)

Microbiology Biocentre, University of Würzburg, Würzburg, Germany.

Alessandro Rufini (A)

Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy.
University of Leicester, Leicester Cancer Research Centre, Leicester, UK.

Kevin M Ryan (KM)

School of Cancer Sciences, University of Glasgow, Glasgow, UK.
Cancer Research UK Beatson Institute, Glasgow, UK.

Kristopher A Sarosiek (KA)

John B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA.
Department of Systems Biology, Lab of Systems Pharmacology, Harvard Program in Therapeutics Science, Harvard Medical School, Boston, MA, USA.
Department of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, USA.

Akira Sawa (A)

Johns Hopkins Schizophrenia Center, Johns Hopkins University, Baltimore, MD, USA.

Emre Sayan (E)

Faculty of Medicine, Cancer Sciences Unit, University of Southampton, Southampton, UK.

Kate Schroder (K)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.

Luca Scorrano (L)

Department of Biology, University of Padua, Padua, Italy.
Veneto Institute of Molecular Medicine, Padua, Italy.

Federico Sesti (F)

Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, NJ, USA.

Feng Shao (F)

National Institute of Biological Sciences, Beijing, PR China.

Yufang Shi (Y)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
The Third Affiliated Hospital of Soochow University and State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University, Suzhou, Jiangsu, China.
CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

Giuseppe S Sica (GS)

Department of Surgical Science, University Tor Vergata, Rome, Italy.

John Silke (J)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Hans-Uwe Simon (HU)

Institute of Pharmacology, University of Bern, Bern, Switzerland.
Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.

Antonella Sistigu (A)

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.

Anastasis Stephanou (A)

European University Cyprus, School of Medicine, Nicosia, Cyprus.

Brent R Stockwell (BR)

Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.

Flavie Strapazzon (F)

IRCCS Fondazione Santa Lucia, Rome, Italy.
Univ Lyon, Univ Lyon 1, Physiopathologie et Génétique du Neurone et du Muscle, UMR5261, U1315, Institut NeuroMyogène CNRS, INSERM, Lyon, France.

Andreas Strasser (A)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Liming Sun (L)

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

Erwei Sun (E)

Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.

Qiang Sun (Q)

Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.

Gyorgy Szabadkai (G)

Department of Biomedical Sciences, University of Padua, Padua, Italy.
Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, UK.

Stephen W G Tait (SWG)

School of Cancer Sciences, University of Glasgow, Glasgow, UK.
Cancer Research UK Beatson Institute, Glasgow, UK.

Daolin Tang (D)

Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Nektarios Tavernarakis (N)

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Crete, Greece.

Carol M Troy (CM)

Departments of Pathology & Cell Biology and Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.

Boris Turk (B)

Department of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia.
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.

Nicoletta Urbano (N)

Department of Oncohaematology, University of Rome Tor Vergata, TOR, Rome, Italy.

Peter Vandenabeele (P)

VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Methusalem Program, Ghent University, Ghent, Belgium.

Tom Vanden Berghe (T)

VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Infla-Med Centre of Excellence, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Matthew G Vander Heiden (MG)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Dana-Farber Cancer Institute, Boston, MA, USA.

Jacqueline L Vanderluit (JL)

Division of BioMedical Sciences, Memorial University, St. John's, NL, Canada.

Alexei Verkhratsky (A)

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Achucarro Center for Neuroscience, IKERBASQUE, Bilbao, Spain.
School of Forensic Medicine, China Medical University, Shenyang, China.
State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.

Andreas Villunger (A)

Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
The Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences (OeAW), Vienna, Austria.
The Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Vienna, Austria.

Silvia von Karstedt (S)

Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Anne K Voss (AK)

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

Karen H Vousden (KH)

The Francis Crick Institute, London, UK.

Domagoj Vucic (D)

Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.

Daniela Vuri (D)

Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.

Erwin F Wagner (EF)

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Henning Walczak (H)

Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.

David Wallach (D)

Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.

Ruoning Wang (R)

Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.

Ying Wang (Y)

Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

Achim Weber (A)

University of Zurich and University Hospital Zurich, Department of Pathology and Molecular Pathology, Zurich, Switzerland.
University of Zurich, Institute of Molecular Cancer Research, Zurich, Switzerland.

Will Wood (W)

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Takahiro Yamazaki (T)

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Huang-Tian Yang (HT)

Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

Zahra Zakeri (Z)

Queens College and Graduate Center, City University of New York, Flushing, NY, USA.

Joanna E Zawacka-Pankau (JE)

Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Department of Biochemistry, Laboratory of Biophysics and p53 protein biology, Medical University of Warsaw, Warsaw, Poland.

Lin Zhang (L)

Department of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Haibing Zhang (H)

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

Boris Zhivotovsky (B)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.

Wenzhao Zhou (W)

Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing, China.

Mauro Piacentini (M)

Department of Biology, University of Rome Tor Vergata, Rome, Italy.
National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.

Guido Kroemer (G)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Lorenzo Galluzzi (L)

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. deadoc80@gmail.com.
Sandra and Edward Meyer Cancer Center, New York, NY, USA. deadoc80@gmail.com.
Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. deadoc80@gmail.com.

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