Pediatric chronic myeloid leukemia in myeloid blast crisis.
Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Pediatrics
Journal
Autopsy & case reports
ISSN: 2236-1960
Titre abrégé: Autops Case Rep
Pays: Brazil
ID NLM: 101640070
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
02
2022
accepted:
13
03
2023
medline:
27
4
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
epublish
Résumé
Chronic myeloid leukemia (CML) accounts for 2-3% of childhood leukemias. About 5% of cases present in a blastic phase of CML which clinically and morphologically mimics more common acute leukemias of childhood. We report a case of a 3-year-old male who presented with gradual onset swelling of the abdomen and extremities along with generalized weakness. Examination revealed massive splenomegaly, pallor, and pedal edema. Initial workup showed anemia, thrombocytopenia, and leukocytosis (120,000/uL) with a blast percentage of 35%. Blasts were positive for CD13, CD33, CD117, CD34 and HLA-DR, and stained negative for Myeloperoxidase and Periodic Acid Schiff. Fluorescence in situ hybridization was positive for b3a2/e14a2 junction BCR-ABL1 transcript and negative for RUNX1-RUNX1T1/t(8;21), clinching the diagnosis of CML in myeloid blast crisis. The patient expired within 17 days of diagnosis and initiation of therapy.
Identifiants
pubmed: 37101551
doi: 10.4322/acr.2023.426
pii: acrep122922
pmc: PMC10124558
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2023426Informations de copyright
Copyright: © 2023 The Authors.
Déclaration de conflit d'intérêts
Conflict of interest: None.
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