Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease.
Latino
autosomal dominant Alzheimer's disease
diffusion tensor imaging
ganglion cell layer
inner plexiform layer
optical coherence tomography
outer nuclear layer
retinal thickness
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
22
03
2023
received:
17
01
2023
accepted:
27
03
2023
pmc-release:
27
10
2024
pubmed:
27
4
2023
medline:
27
4
2023
entrez:
27
4
2023
Statut:
ppublish
Résumé
We investigated the correlation between retinal thickness and optic tract integrity in subjects with autosomal dominant Alzheimer's disease (ADAD) causing mutations. Retinal thicknesses and diffusion tensor images (DTI) were obtained using optical coherence tomography and magnetic resonance imaging, respectively. The association between retinal thickness and DTI measures was adjusted for age, sex, retinotopy, and correlation between eyes. Optic tract mean diffusivity and axial diffusivity were negatively correlated with retinotopically defined ganglion cell inner plexiform thickness (GCIPL). Fractional anisotropy was negatively correlated with retinotopically defined retinal nerve fiber layer thickness. There was no correlation between outer nuclear layer (ONL) thickness and any DTI measure. In ADAD, GCIPL thickness is significantly associated with retinotopic optic tract DTI measures even in minimally symptomatic subjects. Similar associations were not present with ONL thickness or when ignoring retinotopy. We provide in vivo evidence for optic tract changes resulting from ganglion cell pathology in ADAD.
Identifiants
pubmed: 37102308
doi: 10.1002/alz.13100
pmc: PMC10603214
mid: NIHMS1898705
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5103-5113Subventions
Organisme : NIA NIH HHS
ID : U01 AG051218
Pays : United States
Organisme : NIH HHS
ID : UH3NS100614
Pays : United States
Organisme : NIH HHS
ID : R01AG062007
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066530
Pays : United States
Organisme : NIH HHS
ID : U01AG051218
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062007
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS100614
Pays : United States
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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