Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex.
acetylcholine
axon
mouse
neuroscience
noradrenaline
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
27 04 2023
27 04 2023
Historique:
received:
13
07
2022
accepted:
24
04
2023
medline:
5
6
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
epublish
Résumé
Fluctuations in brain and behavioral state are supported by broadly projecting neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to examine spontaneous activity of cholinergic and noradrenergic axons in awake mice in order to determine the interaction between arousal/movement state transitions and neuromodulatory activity across the dorsal cortex at distances separated by up to 4 mm. We confirm that GCaMP6s activity within axonal projections of both basal forebrain cholinergic and locus coeruleus noradrenergic neurons track arousal, indexed as pupil diameter, and changes in behavioral engagement, as reflected by bouts of whisker movement and/or locomotion. The broad coordination in activity between even distant axonal segments indicates that both of these systems can communicate, in part, through a global signal, especially in relation to changes in behavioral state. In addition to this broadly coordinated activity, we also find evidence that a subpopulation of both cholinergic and noradrenergic axons may exhibit heterogeneity in activity that appears to be independent of our measures of behavioral state. By monitoring the activity of cholinergic interneurons in the cortex, we found that a subpopulation of these cells also exhibit state-dependent (arousal/movement) activity. These results demonstrate that cholinergic and noradrenergic systems provide a prominent and broadly synchronized signal related to behavioral state, and therefore may contribute to state-dependent cortical activity and excitability.
Identifiants
pubmed: 37102362
doi: 10.7554/eLife.81826
pii: 81826
pmc: PMC10238096
doi:
pii:
Substances chimiques
Norepinephrine
X4W3ENH1CV
Cholinergic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS118461
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097287
Pays : United States
Informations de copyright
© 2023, Collins et al.
Déclaration de conflit d'intérêts
LC, JF, BE, DM No competing interests declared
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