Mast cells-fetal mast cells crosstalk with maternal interfaces during pregnancy: Friend or foe?
MC
allergic diseases
fetal
immunity
mast cells
maternal
vertical transmission
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
04
03
2023
received:
23
06
2022
accepted:
08
03
2023
medline:
28
4
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
ppublish
Résumé
Mast cells (MC) are hematopoietic immune cells that play a major role during allergic reactions in adults by releasing a myriad of vasoactive and inflammatory mediators. MC seed all vascularized tissues and are most prominent in organs with a barrier function such as skin, lungs, and intestines. These secreted molecules cause mild symptoms such as localized itchiness and sneezing to life-threatening symptoms (i.e., anaphylactic shock). Presently, despite the extensive research on Th2-mediated immune responses in allergic diseases in adults, we are still unable to determine the mechanisms of the role of MC in developing pediatric allergic (PA) disorders. In this review, we will summarize the most recent findings on the origin of MC and discuss the underappreciated contribution of MC in the sensitization phase to maternal antibodies during pregnancy in allergic reactions and other diseases such as infectious diseases. Then, we will lay out potential MC-dependent therapeutic strategies to be considered in future investigations to understand the remaining gaps in MC research for a better quality of life for these young patients.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13943Informations de copyright
© 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Références
Aldakheel FM. Allergic diseases: a comprehensive review on risk factors, immunological mechanisms, link with COVID-19, potential treatments, and role of allergen bioinformatics. Int J Environ Res Public Health. 2021;18:12105.
Vandenbulcke L, Bachert C, Van Cauwenberge P, Claeys S. The innate immune system and its role in allergic disorders. Int Arch Allergy Immunol. 2006;139:159-165.
World Health Organization Asthma. Accessed June 16, 2022. Available online: https://www.who.int/news-room/fact-sheets/detail/asthma 2021.
Menu SS. Research points to increasing problems relating to hypersensitivity to food. 1-10.
Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJ. Fatal anaphylaxis: mortality rate and risk factors. J Allergy Clin Immunol Pract. 2017;5:1169-1178.
Fujimura T, Lum SZC, Nagata Y, Kawamoto S, Oyoshi MK. Influences of maternal factors over offspring allergies and the application for food allergy. Front Immunol. 2019;10:1-26.
Gupta RS, Springston EE, Warrier MR, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9-e17.
Yang CL, Gaffin JM, Radhakrishnan D. Question 3: can we diagnose asthma in children under the age of 5 years? Paediatr Respir Rev. 2019;29:25-30.
Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K. Gastrointestinal food allergy in infants. Allergol Int. 2013;62:297-307.
Biagini JM, Myers, PhD1 and Gurjit K. Khurana Hershey, MD, PhD1, 2. Eczema in early life. Genetics, the skin barrier, and lessons learned from birth cohort studies. J Pediatr. 2010;157:704-714.
Paul WE, Zhu J. How are T H 2-type immune responses initiated and amplified? $watermark-text $watermark-text $watermark-text. Nat Rev Immunol. 2010;10:225-235.
Pasha MA, Patel G, Hopp R, Yang Q. Role of innate lymphoid cells in allergic diseases. Allergy Asthma Proc. 2019;40:138-145.
Soyer OU, Akdis M, Ring J, et al. Mechanisms of peripheral tolerance to allergens. Allergy. 2012;68:161-170. doi:10.1111/all.12085
Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 2010;30:269-280.
Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 2003;112:118-127.
Alvaro-Lozano M, Akdis CA, Akdis M, et al. EAACI allergen immunotherapy User's guide. Pediatr Allergy Immunol. 2020;31:1-101.
Pajno GB, Bernardini R, Peroni D, et al. Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report. Ital J Pediatr. 2017;43:1-18.
Qi Y, Shi P, Chen R, et al. Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016-2018: a multicenter, retrospective study. BMC Pediatr. 2021;21:1-10.
Olin A, Henckel E, Chen Y, et al. Stereotypic immune system development in newborn children. Cell. 2018;174:1277-1292.e14.
Li Z, Liu S, Xu J, et al. Adult connective tissue-resident mast cells originate from late Erythro-myeloid progenitors. Immunity. 2018;640-653:640-653.e5. doi:10.1016/j.immuni.2018.09.023
de Benedictis FM, Attanasi M. Asthma in childhood. Eur Respir Rev. 2016;25:41-47.
Devonshire AL, Kumar R. Pediatric asthma: principles and treatment. Allergy Asthma Proc. 2019;40:389-392.
Haktanir Abul M, Phipatanakul W. Severe asthma in children: Evaluation and management. Allergol Int. 2019;68:150-157.
Tontini C, Bulfone-Paus S. Novel approaches in the inhibition of IgE-induced mast cell reactivity in food allergy. Front Immunol. 2021;12:613461.
Stephen J. Galli1, 2 and Mindy Tsai1. IgE and mast cells in allergic disease. Nat Med. 2013;18:693-704.
Kolkhir P, Elieh-Ali-Komi D, Metz M, Siebenhaar F, Maurer M. Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases. Nat Rev Immunol. 2022;22:294-308.
Siebenhaar F, Redegeld FA, Bischoff SC, Gibbs BF, Maurer M. Mast cells as drivers of disease and therapeutic targets. Trends Immunol. 2018;39:151-162.
Redegeld FA, Yu Y, Kumari S, Charles N, Blank U. Non-IgE mediated mast cell activation. Immunol Rev. 2018;282:87-113.
Galli SJ, Gaudenzio N, Tsai M. Mast cells in inflammation and disease: recent Progress and ongoing concerns. Annu Rev Immunol. 2020;38:49-77.
Shamji MH, Sharif H, Layhadi JA, Zhu R, Kishore U, Renz H. Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma. J Allergy Clin Immunol. 2022;149:791-801.
Kitamura Y, Oboki K, Ito A. Development of mast cells. Proc Jpn Acad Ser B Phys Biol Sci. 2007;83:164-174.
Dahlin JS, Maurer M, Metcalfe DD, Pejler G, Sagi-Eisenberg R, Nilsson G. The ingenious mast cell: contemporary insights into mast cell behavior and function. Allergy. 2022;77:83-99.
Dwyer DF, Barrett NA, Austen KF, Immunological T, Consortium GP. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2017;17:69-81.
Mittal A, Sagi V, Gupta M, Gupta K. Mast cell neural interactions in health and disease. Front Cell Neurosci. 2019;13:1-6.
Gentek R, Ghigo C, Hoeffel G, et al. Hemogenic endothelial fate mapping reveals dual developmental origin of mast cells. Immunity. 2018;48:1160-1171.e5.
Tahereh Derakhshan P, Boyce JA, Dwyer DF. Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis. J Allergy Clin Immunol. 2022;150:739-747.
Popescu DM, Botting RA, Stephenson E, et al. Decoding human fetal liver haematopoiesis. Nature. 2019;574:365-371.
Mass E, Gentek R. Fetal-derived immune cells at the roots of lifelong pathophysiology. Front Cell Dev Biol. 2021;9:1-17.
Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A. Mast cells occupy stable clonal territories in adult steady-state skin. J Invest Dermatol. 2020;140:2433-2441.e5.
Derakhshan T, Samuchiwal SK, Hallen N, et al. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021;218:1-15.
van Nieuwenhoven ALV, Heineman MJ, Faas MM. The immunology of successful pregnancy. Hum Reprod Update. 2003;9:347-357.
Aagaard-Tillery KM, Silver R, Dalton J. Immunology of normal pregnancy. Semin Fetal Neonatal Med. 2006;11:279-295.
Vendola N, Stampini V, Amadori R, Gerbino M, Curatolo A, Surico D. Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-19 pneumonia. Eur J Obstet Gynecol Reprod Biol. 2020;253:331-332.
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-815.
Wilcox CR, Jones CE. Beyond passive immunity: is there priming of the fetal immune system following vaccination in pregnancy and what are the potential clinical implications? Front Immunol. 2018;9:1548.
Albrecht M, Arck PC. Vertically transferred immunity in neonates: mothers, Mechanisms and Mediators. Front Immunol. 2020;11:1-14.
Cook-Mills JM. Maternal influences over offspring allergic responses. Curr Allergy Asthma Rep. 2015;15:1-18.
Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019;4:eaatt6114.
Sonnenschein-van der Voort AMM, Jaddoe VWV, Moll HA, et al. Influence of maternal and cord blood C-reactive protein on childhood respiratory symptoms and eczema. Pediatr Allergy Immunol. 2013;24:469-475.
Msallam R, Balla J, APS R, et al. Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Science. 2020;370:941-950.
Yamaguchi M, Lantz CS, Oettgen HC, et al. IgE enhances mouse mast cell fc (epsilon) RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med. 1997;185:663-672.
McGovern N, Chan JKY, Ginhoux F. Dendritic cells in humans--from fetus to adult. Int Immunol. 2014;27:65-72.
McGovern N, Shin A, Low G, et al. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature. 2017;546:662-666.
Elahi S, Ertelt JM, Kinder JM, et al. Host Defence against infection. Nature. 2013;504:158-162.
Foong RX, Santos AF. Biomarkers of diagnosis and resolution of food allergy. Pediatr Allergy Immunol. 2021;32:223-233.
Bahri R, Custovic A, Korosec P, et al. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis. J Allergy Clin Immunol. 2018;142:485-496.e16. doi:10.1016/j.jaci.2018.01.043
Cho WK, Mittal SK, Elsayed Elbasiony SKC. Activation of ocular surface mast cells promotes corneal neovascularization. Ocul Surf. 2020;18:857-864.
Dwyer DF, Boyce JA. Neonatal mast cells and transplacental IgE transfer: a mechanism of disease inheritance or of passive infant barrier defense? J Allergy Clin Immunol. 2021;148:76-77.
Minton K. Maternal sensitization to neonatal allergy. Nature Rev Immunol. 2021;21:2-3.
Rothenberg ME. Transferring allergies in the womb. Science. 2020;370:907-909.
de Las Vecillas L, Eguiluz-Gracia I, Giovannini M. You might owe your mother more than you think. Allergy. 2021;76:3236-3237.
Bundhoo A, Paveglio S, Rafti E, Dhongade A, Blumberg RS, Matson AP. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes. Clin Exp Allergy. 2015;45:1085-1098.
Shamji MH, Valenta R, Jardetzky T, et al. The role of allergen-specific IgE, IgG and IgA in allergic disease. Allergy. 2021;76:3627-3641.
Raposo G, Tenza D, Mecheri S, Peronet R, Bonnerot C, Desaymard C. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol Biol Cell. 1997;8:2631-2645.
Dudeck J, Medyukhina A, Fröbel J, et al. Mast cells acquire MHC II from dendritic cells during skin inflammation. J Exp Med. 2017;214:3791-3811.
Elieh Ali Komi D, Shafaghat F, Kovanen PT, Meri S. Mast cells and complement system: Ancient interactions between components of innate immunity. Allergy. 2020;75:2818-2828.
Tang M, Jia F, Nan F, et al. Role of cytokines in Thymic regulatory T cell generation: overview and updates. Front Immunol. 2022;13:1-8.
Plitas G, Rudensky AY. Regulatory T cells: differentiation and function George. Cancer Immunol Res. 2016;4:721-725.
Holmes-Liew CL, Holmes M, Beagley L, et al. Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation. Clin Transl Immunol. 2015;4:e35.
Kothari A, Hirschmugl B, Lee JS, et al. The impact of maternal-fetal omalizumab transfer on peanut-specific responses in an ex vivo placental perfusion model. Allergy. 2022;77:3684-3686. doi:10.1111/all.15468
Urb M, Sheppard DC. The role of mast cells in the defence against pathogens. PLoS Pathog. 2012;8:2-4.
Kopanja S, Gattinger P, Schmidthaler K, et al. Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population. Pediatr Allergy Immunol. 2022;33:1-10.
Nampijja M, Apule B, Lule S, et al. Effects of maternal worm infections and anthelminthic treatment during pregnancy on infant motor and neurocognitive functioning. J Int Neuropsychol Soc. 2012;18:1019-1030.
Corbeil LB, Campero CM, Rhyan JC, et al. Uterine mast cells and immunoglobulin-E antibody responses during clearance of tritrichomonas foetus. Vet Pathol. 2005;42:282-290.
McSorley HJ, Chayé MAM, Smits HH. Worms: pernicious parasites or allies against allergies? Parasite Immunol. 2019;41:1-13.
Carlier Y, Truyens C, Deloron P, Peyron F. Congenital parasitic infections: a review. Acta Trop. 2012;121:55-70.
Oykhman P, Kim HL, Ellis AK. Allergen immunotherapy in pregnancy. Allergy Asthma Clin Immunol. 2015;11:1-5.