Chemical Strategies toward Prodrugs and Fluorescent Probes for Gasotransmitters.
carbon monoxide
gasotransmitter
hydrogen sulfide
nitric oxide
probe
prodrug
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
27 Apr 2023
27 Apr 2023
Historique:
received:
28
11
2022
revised:
03
02
2023
accepted:
20
02
2023
medline:
27
4
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
aheadofprint
Résumé
Three gaseous molecules are widely accepted as important gasotransmitters in mammalian cells, namely NO, CO and H2S. Due to the pharmacological effects observed in preclinical studies, these three gasotransmitters represent promising drug candidates for clinical translation. Fluorescent probes of the gasotransmitters are also in high demand; however, the mechanisms of actions or the roles played by gasotransmitters under both physiological and pathological conditions remain to be answered. In order to bring these challenges to the attention of both chemists and biologists working in this field, we herein summarize the chemical strategies used for the design of both probes and prodrugs of these three gasotransmitters.
Identifiants
pubmed: 37102481
pii: MRMC-EPUB-131278
doi: 10.2174/1389557523666230427152234
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.