Comparison of spinal magnetic resonance imaging and classical clinical factors in predicting motor capacity in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis
Biomarkers
Disease progression rate
Motor neuron disorder
Spinal cord MRI
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
19
03
2023
accepted:
12
04
2023
revised:
10
04
2023
medline:
17
7
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
ppublish
Résumé
Motor capacity is crucial in amyotrophic lateral sclerosis (ALS) clinical trial design and patient care. However, few studies have explored the potential of multimodal MRI to predict motor capacity in ALS. This study aims to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors. Spinal multimodal MRI was performed shortly after diagnosis in 41 ALS patients and 12 healthy participants as part of a prospective multicenter cohort study, the PULSE study (NCT00002013-A00969-36). Motor capacity was assessed using ALSFRS-R scores. Multiple stepwise linear regression models were constructed to predict motor capacity at 3 and 6 months from diagnosis, based on clinical variables, structural MRI measurements, including spinal cord cross-sectional area (CSA), anterior-posterior, and left-to-right cross-section diameters at vertebral levels from C1 to T4, and diffusion parameters in the lateral corticospinal tracts (LCSTs) and dorsal columns. Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. And as early as 3 months from diagnosis, structural MRI measurements fit the best multiple linear regression model to predict the total ALSFRS-R (R Spinal multimodal MRI could be promising as a tool to enhance prognostic accuracy and serve as a motor function proxy in ALS.
Sections du résumé
BACKGROUND
BACKGROUND
Motor capacity is crucial in amyotrophic lateral sclerosis (ALS) clinical trial design and patient care. However, few studies have explored the potential of multimodal MRI to predict motor capacity in ALS. This study aims to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors.
METHODS
METHODS
Spinal multimodal MRI was performed shortly after diagnosis in 41 ALS patients and 12 healthy participants as part of a prospective multicenter cohort study, the PULSE study (NCT00002013-A00969-36). Motor capacity was assessed using ALSFRS-R scores. Multiple stepwise linear regression models were constructed to predict motor capacity at 3 and 6 months from diagnosis, based on clinical variables, structural MRI measurements, including spinal cord cross-sectional area (CSA), anterior-posterior, and left-to-right cross-section diameters at vertebral levels from C1 to T4, and diffusion parameters in the lateral corticospinal tracts (LCSTs) and dorsal columns.
RESULTS
RESULTS
Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. And as early as 3 months from diagnosis, structural MRI measurements fit the best multiple linear regression model to predict the total ALSFRS-R (R
CONCLUSIONS
CONCLUSIONS
Spinal multimodal MRI could be promising as a tool to enhance prognostic accuracy and serve as a motor function proxy in ALS.
Identifiants
pubmed: 37103756
doi: 10.1007/s00415-023-11727-w
pii: 10.1007/s00415-023-11727-w
doi:
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3885-3895Investigateurs
Veronique Danel-Brunaud
(V)
Caroline Moreau
(C)
Thierry Perez
(T)
None Dumont
K Dujardin
(K)
Arnaud Delval
(A)
Patrick Gelé
(P)
Marie Pleuvret
(M)
Valerie Santraine
(V)
Francine Niset
(F)
Julien Dumont
(J)
Victor Laugeais
(V)
Mathilde Bon
(M)
Thavarak Ouk
(T)
Camille Potey
(C)
Celine Leclercq
(C)
Elise Gers
(E)
Francois Salachas
(F)
Gaelle Bruneteau
(G)
Lucette Lacomblez
(L)
Julie Socha
(J)
Fanny Pineau
(F)
Timothee Lenglet
(T)
Patricia Doucelance Stéphanie Folhinha
(PDS)
Amandine Bordet
(A)
Hugo Royer
(H)
Nadia Osman
(N)
Sabah Ait Khelifa
(SA)
Philippe Corcia
(P)
Stephane Beltran
(S)
Delphine Carmier
(D)
Laurent Barantin
(L)
Hélène Blasco
(H)
Salah Eddine Bakkouche
(SE)
Mohad Mouzouri
(M)
Jean-Christophe Antoine
(JC)
Jean-Philippe Camdessanché
(JP)
Nathalie Dimier
(N)
Anne-Laure Kaminsky
(AL)
Isabelle Court-Fortune
(I)
Claire Boutet
(C)
Philippe Gonzalo
(P)
Vincent Visneux
(V)
Karine Ferraud
(K)
Georgette Berlier
(G)
Steeve Genestet
(S)
Christophe Gut-Gobert
(C)
Douraied Ben Salem
(DB)
Pauline Nicolas
(P)
Sabine Larvor
(S)
Kevin Mouly
(K)
Liana Le Roux
(LL)
Kevin Postec
(K)
Camille Bezeazux
(C)
Sylvain Rosec
(S)
Hélène Fortin-Prunier
(H)
Gaelle Novert
(G)
Elsa Menanteau
(E)
Kevin Postec
(K)
Magali Denizot
(M)
Emilien Bernard
(E)
Christophe Vial
(C)
Emmanuel Broussole
(E)
Juliette Svahn
(J)
Pierre Le Cam
(PL)
Yves Berthezene
(Y)
Philippe Combet
(P)
Sophie Jacqueline
(S)
Camille Neuillet
(C)
Adeline Mansuy
(A)
William Camu
(W)
None Juntas-Morates
None Pageot
None Esselin
None Champfleur
None Roy-Bellina
Sylvain Lehmann
(S)
Sebastien Alphandry
(S)
Laura Labar
(L)
Leandra Baudesson
(L)
Sharam Attarian
(S)
Aude-Marie Grapperon
(AM)
Jean Pouget
(J)
Annie Verschueren
(A)
Jaochim Bas
(J)
Armelle Finet-Monnier
(A)
Carole Belingher
(C)
Saran Diallo
(S)
Nacime Heddadji
(N)
Sebastien Alphandery
(S)
Leandra Baudesson
(L)
Pascale Reginensi
(P)
Claude Desnuelle
(C)
Marie-Hélene Soriani
(MH)
S Chanalet
(S)
Lydiane Mondot
(L)
None Puma
Isabelle Pruvost
(I)
Carole Barré
(C)
Pascal Cintas
(P)
Marie-Christine Arne Bes
(MA)
Blandine Acket
(B)
Jérémie Pariente
(J)
Isabelle Guilbaud
(I)
Fabrice Bonneville
(F)
E Causse
(E)
Thierry Lagarde
(T)
Jeremy Geffroy
(J)
Magali Centelles
(M)
Véronique Hermet-Douard
(V)
Sophie Pittion-Vouyovitch
(S)
Maud Michon
(M)
Mylène Meyer
(M)
Sandra Lomazzi
(S)
Gabriella Hossu
(G)
Anne Chatelain
(A)
Philippe Couratier
(P)
Geraldine Lautrette
(G)
Francois Vincent
(F)
Larie-Therese Antonini
(LT)
Florent Favard
(F)
M L Arie-Paule Boncoeur-Martel
(MLA)
Marianne Chouly
(M)
Jean-Claude Desport
(JC)
Pierre Jesus
(P)
Phillipe Fayemendy
(P)
Clémence Labetoulle
(C)
Julie Catteau
(J)
Olivier Villeneuve
(O)
Selam Machat
(S)
Nathalie Guy
(N)
Pierre Clavelou
(P)
Anick Greil
(A)
M Duclos
(M)
Betty Jean
(B)
Carine Chassain
(C)
Camille Tsoutsos
(C)
Claudine Speziale
(C)
Aurélie Cladiere
(A)
C Bouteloup
(C)
N Farigon
(N)
Sophia Sickout Argondo
(SS)
Emilie Dumont
(E)
Sandrine Rouvet
(S)
Fausto Viader
(F)
Mathilde Lefilliatre
(M)
Philippe Mouton
(P)
A Mondou
(A)
Stephane Allouche
(S)
Rachida Bari-Makouri
(R)
Ivan Kolev
(I)
Morgane Pihan
(M)
Helene Le Ho
(HL)
Bertrand Catroux
(B)
Maela Castel
(M)
Marine Rigal
(M)
Catherine Bellot
(C)
Maelle Vomscheid
(M)
Marie-Cécile Hervé
(MC)
Marie-Pierre Duban
(MP)
Anne Vieillart
(A)
Julien Cassereau
(J)
Philippe Codron
(P)
Vivien Pautot
(V)
Nicole Meslier
(N)
Wojciech Trzepizur
(W)
J Y Tanguy
(JY)
Philippe Allain
(P)
Cecile Thiery
(C)
Pascal Reynier
(P)
Tiphaine Barbe
(T)
None Vialle-Soubranne
Nathalie Vienne
(N)
Audrey Olivier
(A)
Jeanne Miller
(J)
Marie Bost
(M)
None Fournier
David Gay
(D)
Robin Bonicel
(R)
Fouzia El Mountassir
(F)
Clara Fischer
(C)
Jean-François Mangin
(JF)
Marie Chupin
(M)
Yann Cointepas
(Y)
Bertrand Accart
(B)
Patrick Gelé
(P)
Florine Fievet
(F)
Matthieu Chabel
(M)
Virginie Derenaucourt
(V)
Loïc Facon
(L)
Yanick Tchantchou Njosse
(YT)
Michael Hisbergues
(M)
None Deplanque
Christine Tabuenca
(C)
Marie-France Cazalère
(MF)
Philippe Couratier
(P)
William Camu
(W)
Philippe Corcia
(P)
Claude Desnuelle
(C)
Maxime Caillier
(M)
Véronique Danel
(V)
Caroline Morerau
(C)
Victor Laugeais
(V)
Amelie Lecocq
(A)
Nathalie Potin
(N)
Marie Frisch
(M)
Marie Léon
(M)
David Devos
(D)
François Salachas
(F)
Pierre-Francois Pradat
(PF)
Lucette Lacomblez
(L)
Jean-Philippe Camdessanché
(JP)
Sharam Attarian
(S)
Timothée Langlet
(T)
Hélène Blasco
(H)
Luc Dupuis
(L)
Mathilde Bon
(M)
Emilien Bernard
(E)
Julien Cassereau
(J)
Marie-Hélène Soriani
(MH)
Cedric Raoul
(C)
Sylvain Lehman
(S)
Sabine Turgeman
(S)
Valérie Goutines
(V)
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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