Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.
adrenomedullin
biomarkers
cardiovascular diseases
clinical trial
migraine disorders
prognosis
therapeutics
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
28 04 2023
28 04 2023
Historique:
pmc-release:
28
04
2024
medline:
1
5
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
ppublish
Résumé
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a variety of cardiovascular-related pathophysiologies. Thus, there is strong supporting evidence encouraging the exploration of the AM-CLR (calcitonin receptor-like receptor) signaling pathway as a therapeutic target. This is further bolstered because several drugs targeting the shared CGRP (calcitonin gene-related peptide)-CLR pathway are already Food and Drug Administration-approved and on the market for the treatment of migraine. In this review, we summarize the AM-CLR signaling pathway and its modulatory mechanisms and provide an overview of the current understanding of the physiological and pathological roles of AM-CLR signaling and the yet untapped potentials of AM as a biomarker or therapeutic target in cardiac and vascular diseases and provide an outlook on the recently emerged strategies that may provide further boost to the possible clinical applications of AM signaling.
Identifiants
pubmed: 37104556
doi: 10.1161/CIRCRESAHA.123.321673
pmc: PMC10155262
mid: NIHMS1885695
doi:
Substances chimiques
Adrenomedullin
148498-78-6
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Receptor Activity-Modifying Protein 2
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1202Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL163885
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119145
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129086
Pays : United States
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