Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine.
precision medicine
sex characteristics
sex differences
sexual dimorphism
stem cells
tissue models
Journal
Annual review of biomedical engineering
ISSN: 1545-4274
Titre abrégé: Annu Rev Biomed Eng
Pays: United States
ID NLM: 100883581
Informations de publication
Date de publication:
08 06 2023
08 06 2023
Historique:
pmc-release:
08
06
2024
medline:
12
6
2023
pubmed:
27
4
2023
entrez:
27
4
2023
Statut:
ppublish
Résumé
Although sex differences have been noted in cellular function and behavior, therapy efficacy, and disease incidence and outcomes, the adoption of sex as a biological variable in tissue engineering and regenerative medicine remains limited. Furthering the development of personalized, precision medicine requires considering biological sex at the bench and in the clinic. This review provides the basis for considering biological sex when designing tissue-engineered constructs and regenerative therapies by contextualizing sex as a biological variable within the tissue engineering triad of cells, matrices, and signals. To achieve equity in biological sex within medicine requires a cultural shift in science and engineering research, with active engagement by researchers, clinicians, companies, policymakers, and funding agencies.
Identifiants
pubmed: 37104652
doi: 10.1146/annurev-bioeng-092222-030857
pmc: PMC10312304
mid: NIHMS1907520
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-331Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL130493
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK108736
Pays : United States
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