Inborn Errors of Immunity.

Humans Immune System Diseases / diagnosis
Antibiotic prophylaxis Antibody deficiency Combined immunodeficiency Hematopoietic stem cell transplantation Immunodeficiency Immunoglobulin replacement Inborn errors of immunity Recurrent infection(s)

Journal

Primary care
ISSN: 1558-299X
Titre abrégé: Prim Care
Pays: United States
ID NLM: 0430463

Informations de publication

Date de publication:
Jun 2023
Historique:
medline: 1 5 2023
pubmed: 28 4 2023
entrez: 27 4 2023
Statut: ppublish

Résumé

Inborn errors of immunity occur in 1 in 1000 to 1 in 5000 individuals and are characterized by immune deficiency and immune dysregulation. The primary care provider (PCP) should be familiar with key features of these diagnoses including recurrent and/or severe infections, hyperinflammation, malignancy, and autoimmunity and have a low threshold to refer for evaluation. The PCP can begin a laboratory evaluation before referral by sending a complete blood count (CBC) with differential, antibody levels, vaccine titers, and possibly other tests. Management approaches vary from antibiotic prophylaxis to hematopoietic stem cell transplantation depending on the specific diagnosis.

Identifiants

DOI: 10.1016/j.pop.2022.12.001 PMID: 37105605
pubmed: 37105605
pii: S0095-4543(22)00144-0
doi: 10.1016/j.pop.2022.12.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

253-268

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Carolyn H Baloh (CH)

Division of Allergy and Clinical Immunology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, 60 Fenwood Road, BTM/Hale Building, 5th Floor, Boston, MA 02115, USA. Electronic address: cbaloh@bwh.harvard.edu.

Hey Chong (H)

Division of Allergy and Immunology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, AOB 3300, Pittsburgh, PA 15224, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inborn Errors of Immunity.
questionsmedicales.fr › Maladies du système immunitaire › Inborn Errors of Immunity.